- - ..
( ):
Panok® (BM Labs)
P.C.M.® (Napp)
I: Nevral® (Lepetit)
Puernol® (Formenti)
Tachipirina® (Angelini) und Komb.-Praparate J: Pyrinazin® (Yamanouchi)
USA: Minotal®(Carnrick)-Komb.
Phrenilin® (Carnrick)-Komb.
Tylenol® with Codeine (McNeil)-Komb.
Paraethoxycain - Paraflutizid - Paramethadion P 685
Paraethoxycain
(Parethoxycain)
94-23-5
136-46-9
Lokalanastheticum
Hydrochlorid
: benzoic acid, 4-ethoxy-, 2-(diethylamino)ethyl ester
H5C2O
-COOH SQC-'> H5C20
Cl
MO-CH2-CH2-N
2- Diethylammoethanol
i-Ethoxybenzoesaure
4-Ethoxybenzoylchlorid
USP 2 404 691 (Squibb; ert. 1946; Prior. 1937,1944). F: Maxieaine® (Fumouze)
H5C2O
C2Hs
0- CH2-CH2-N
C2H5
Paraethoxycain
Paraflutizid
1580-83-2
Diureticum
6-chloro-3,4-dihydro-3-(p-fluorobenzyl)-2 H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide ho-ch,-ch2^0>-f
h2n - nh2
6-Amino-i-chlorberzol-
l^-disulfamid
(s. S. 195)
2-(Д-Fluor phenyl)-ethanol
c,yyvCH2^^~f
h2n-so/^s'nh
02
Paraflutizid
GB-P 961 641 (Lab. Dausse; Anm. 31.7.1962; F-Prior. 31.7.1961).
D: Detensitral® (Karlspharma)-Komb.
F: Divimax® (Dausse)-Komb. Tensitral® (Dausse)-Komb.
Paramethadion
(Isoethadion)
115-67-3
Antiepilepticum
5-ethyl-3,5-dimethyloxazolidine-2,4-dione
686 P Paramethadion - Paramethason
H5°4 NaCN C=0 -!
H3C
Methylethyl-
keton
H5C2 OH
V
H3C^ 4CN
2-Hydroxy-2-
methylbutyronitril
H5C2. OH
cN
H3C^ COOCjHs
2-Hydroxy-2-methyl-
buttersaureethylester
HfiC* Q
CX Г NaOCHi / (CH?0);$Cb
Л-N Oimrthyl- *
О H sulfat
5-Ethyl - 5 -
methyl-oxaze-
[idin-2,4-dion
H5C2
H3C
‘ijy
Нь
I Paramethadion
USP 2 575 693 (Abbott; ert. 1951; Anm. 1949).
F: Paradione® (Abbott) GB: Paradione® (Abbott)
USA: Paradione®(Abbott)
Paramethason
53-33-8
2145-14-4 Dinatriumphosphat 1597-82-6 Acetat
Glucocorticoid
6 a-fluoro-11A17,21 -trihydroxy-16a-methylpregna-1,4-diene-3,20-dione H3CV
О
II
fy ''o-OH CHC1, .
^XOOH Monoperphthalsaure
H3C-CO-16a-Methylpregnenolon-3;5-acetat
H3C-CO-O'
-CH3
(НзС-С0)20/НэС-СО-С|
H3C-C0-0'
Paramethason P 687
I H3C-C0-0-CH2,
CH3
Dinatriumphosphat:
HO-CH2. HO^
Paramethason-acetat
1 ^_nJ p—Ci / [Pyridin ]
2. saurer lonenaustauschef / NaHCO,
3 NaOH/pH8
1. Dimorpholinophosptxiroxychlortd
Paramethason-21-di-Na-phosphat j
Paramethason
USP 2 671 752 (Syntex; ert. 1954; Anm. 1951).
C. Djerassi et al., J. Am. Chem. Soc. 82, 2318 (I960).
Ausgangsverbindung:
R. E. Marker. H. M. Crooks, J. Am. Chem. Soc. 64, 1280 (1942).
Weitere Verfahren:
USP 3 557 158 (Upjohn; ert. 19.1.1971; Anm. 22.1.1962; Prior. 4.8.1958). P. Schneider et al., J. Am. Chem. Soc. 81, 3167 (1959).
GB-P 850 263 (Organon; Anm. 30.4.1959; NL-Prior. 12.5.1958).
USP 4041 055 (Upjohn; ert. 9.8.1977; Anm. 17.11.1975). Dinatriumphosphat:
DBP 1 134 075 (Merck AG; Anm. 26.11.1959).
D: Monocortin® (Griinenthal)
Monocortin® S (Griinenthal)-Dinatriumphosphat
F: Dilar® (Cassenne)
GB: Haldrate® (Lilly)
Metilar® (Syntex)
I: Alfa-6 (Sam)
Paramezone® (Recordati)
J: Haldron® (Dainippon)
Parame® A (Syntex-Tanabe)-Komb. Paramesone® (Syntex-Tanabe)
USA: Haldrone® (Lilly)
Stemex® (Syntex)
Stero-Darvon® (Lilly)-Komb.
688 P Pargylin - Paromomycin
Pargylin
555-57-7 306-07-0 Hydrochlorid
MAO-lnhibitor;
Antihypertonicum
/V-methyl-'Y-2-propynylbenzylamine
CH3
+ Br
-CH2-C=CH
Na,COi
W-BenzylmethyJamin Propargylbromid
DOT 9,217(1973). USP 3 155 584 (Abbott; ert. 3.11.1964; Prior. 3.12.1962).
F: Euditron® (Abbott)-Komb. GB: Eutonyl® (Abbott)
USA: Eutonyl® (Abbott)
Eutron® (Abbott)-Komb.
Paromomycin 7542-37-2 Antibioticum
(Aminosidin) 1263-89-4 Sulfat
* streptamine, 0-2-amino-2-deoxy-a-D-glucopyranosyl-(l^*4)-O-[O2,6-diamino-2,6-dideoxy-/?-L-idopyranosyl-(l—»3)-/?-D-ribofuranosyl-(l—*5)]-2-deoxy-
Aus Fermentationslosungen von Streptomyces rimosus forma paromomycinus oder Streptomyces Krestomyceticus N.C.I.B. 8995.
USP 2 916 485 (Parke-Davis; ert. 8.12.1959; Prior. 12.1.1959). GB-P 880035 (Soc. Farmac. Italia; Anm. 31.3.1959; Laufzeit ab 18.2.1960).
D: Gabbromycin® (Montedison Farma) Humatin® (Parke-Davis)
F: Humagel® (Parke-Davis)
Humatin® (Parke-Davis)
GB: Humatin® (Parke-Davis)
I: Aminoxidin® (Farmalabor) Gabbroral® (Farmalabor) Humatin® (Parke-Davis) Paramicina® (Ragionieri)
J: Humatin® (Parke-Davis-Sankyo) USA: Humatin® (Parke-Davis)
Parsalmid - Pasiniazid - Pecazin P 689
parsal m id 30653-83-9 Antiphlogisticum
5-amino-jV-butyl-2-(2-propynyloxy)benzamide
O-CO-CH3 XOOH
SOC12
NH-CO-CH3
5-Acetamido-O- Thionylchlorid acetylsalicylsaure
0-C0—CH3
xo-ci
1 C4H9NH2 2. MaOH 1. Butylamm
NH-CO-CH3
5-Acetamido-O-
acetylsalicylsaurechlorid
OH
CO-NH-C4H9
NH-CO-CH3
5-Acetamido-A/-butyl-
salicylamid
1 Br—CHj—C=CH / Na i (CH3)2CHOH
2 H2SOt / H;C_
1 Propargylbromid
0-CH2“C=CH CO-NH-C4H9
nh2
Parsalmid
DOF 2, 55 (1977); 3,82 (1978).
DOT 14,164(1978).
DOS 2 029 991 (E.R.A.S.M.E.; Anm. 18.6.1970; GB-Prior. 20.6.1969). USP 3 739 030 (E.R.A.S.M.E.; ert. 12.6.1973; GB-Prior. 20.6.1969).
