- - ..
( ):
D: Fibrinolysin (Human) Lyovac (Sharp + Dohme) USA: Blase® (Parke Davis)
F: Thromboclase® (Choay) Lyovac® (Merck Sharp + Dohme)
I: Elase® (Parke Davis) Thromfeolysin® (Merck Sharp -f Dohme)
Fipexid
34161-24-5 34161-23-4 Hydrochlorid
Antidepressivum;
Psychotonicum
l-[(p-chlorophenoxy)acetyl]-4-piperonylpiperazine
4-Chlorphenoxyacetyl
chlorid
1 - (3, it-MethylendioxybenzyU -piperazm
(} - Piperonyl piperazin)
Fipexid
FP-M 7524 (Lab. F. Bouchard; Anm. 12.3.1968).
F: Vigilor (Bouchard)
Flavoxat
15301-69-6
3717-88-2 Hydrochlorid
Spasmolyticum
2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4W-1 -benzopyran-8-carboxylate
Flavoxat - Floctafenin F 401
COOH
Salicylsaure
CH2-CH3
Cl—C.
Propionylchlorid
COOH
CH2-CH3
2-Propionyioxybenzoe-
saure
[ *' 2-Propionylsalicy)saure'‘)
9C
COOH
'CH2-CH3
3-Carboxy~2-hydroxy-
propiophenon
(3 - Propionylsaiicyisaure I
{<Q^Co) 0 f |^^^-C00Naj , 180 -I90ec 0 SOCl2 0 /N1 CH3
Befttoesaure . anhydrtfl Natnumbenroat COOH o-S, k
3-Metbylflavon-8- 3-Methytflavon-8-
carbonsaure carbonsaurechlorid
СЧ2-ОН
1-12 -Hydroxyethyl1 -piperidin *
(2-P'pertdincethano()
USP 2 921070 (Recordati; ert. 12.1.1960; CH-Prior. 5.11.1957).
Aitern ativsy nthese:
USP 3 350411 (Seceph; ert. 31.10.1967; I-Prior. 10.10.1963).
D: SpasureV® (Asche) J; Bladderon® (Nippon Shinyaku)
GB: Urispas® (Syntex) USA: Unspas®(Smith Kline + French)
I: Getturin Semphce® (Recordati)
Floctafenin 23779-99-9 Analgeticum
2,3-dihydroxypropyl /V-[8-(trifIuoromethyl)-4-quinolyl]-anthranilate
9рз
NH2
2-frifluor-
methyl-
anilin
OC2H5
CH
И
^.c
Н5С2СЮС COOC2H5
Etboxymethvlenmalon-
saurediethylester
?F3
H5C2OOC C0OC2Hs
COOC2H5
3-Ethoxycarbonyl-4-
hydroxy-e-tnMuor-
methytchinotin
CF3
'COOH
COOCHj
402 F Floctafenin - Flopropion
сооснз
CH3
р+снЭ/1
ЧО~СНг"Со J/NaH/Toluol
2,2-Oimethy(-4-
hydroxymetriyl-1,3-
dioxolan
■0— CH2~
CH%
/°~f-CH3
Vo
HCUH2O
CF3
:0-0-CH2-CH-CH2“0H OH
Floctafenm
DOF 1,59(1976).
DBP 1 815 467 (Roussel-Uclaf; Anm. 18.12.1968; F-Prior. 29.12.1967, 29.3.1968, 23.8.1968). USP 3 644368 (Roussel-Uclaf; ert. 22.2.1972; F-Prior. 29.12.1967, 23.8.1968).
D: Idarac® (Roussel) I: Idarac® (Roussel Maestretti)
F: Idarac® (Diamant)
Flopropion 2295-58-1 Spasrnolyticum
0H 0H NH I CH 0 !
HO -fi * HC-CH?-CH3 ^ !но-/Ч-с° I
—( СН2-СНЭ i —( CH2-CH3
OH OH | OH I
Phloroglucm Propiomtril I Flopropion
11,3,5 -Tfihydroxy-
benzol)
DOT 1, 124(1965).
Canter et al., J. Chem. Soc. 1931,1245.
K. Shinoda, J. Pham. Soc. Jpn. 35,235 (1927).
Howells et al., J. Am. Chem. Soc. 54,2451 (1932). Pharmakologie:
R. Cahen u. A. Boucherie, C. R. Soc. Biol. 157, 112 (1963).
J: Cospanon® (Eisai)
Bilup® (Hishiyama) Compacsul® (Ono)
Cospuron® (Taisho)
Doctoron® (Wakamoto) Epbtanon® (Isei)
Bopione® (Yamagata) Mirithiron® (Hokuriku) Mirulevatin® (Nippon Zoki) Nichipanon® (Nissin Yamagata) Padeskin® (Ohta)
Pasmus® (Daiichi)
Piophen® (Mohan)
Profenon® (Morishita) Pellegal® (Mitsui)
Sartilon® (Zeria)
Spamorin® (Tokyo Tanabe) Supanate® (Nippon Shinyaku) Supazlun® (Kowa)
Sremart® (Zensei)
TrytaJone® (Takata)
TuflU® (Sanwa)
Florantyron - Floredil - Fluanison F 403
Florantyron
519-95-9
Cholereticum
'/-oxo-8-fluoranthenebutyric acid
0
AlClj/Nitrobenzol
Fluoranthen Bernstein-
saurean-hydrid
c-ch2-ch2-cooh
0
Florantyron I
USP 2 560 425 (Miles Labs.; ert. 1951; Prior. 1948).
I: Bilyn® (Janus)
Cistoplex® (Borromeo)
Idroepar® (Beolet)
J: Zanchol® (G.D.-Dainippon) USA: Zanchol® (Searle)
Floredil
53731-36-5
Coronardilatator
4-[2-(3,5-diethoxyphenoxy)ethyl]morpholine
H5c2o
H5C20
3,5-Diethoxyphenol 2-Morpholinoethylchlorid
H5C 2 0
H5C2O
DOS 2020464 (Orsymonde; Anm. 27.4.1970; GB-Prior. 29.4.1969). F: Carfonal® (Lafon)
Fluanison
1480-19-9
Neurolepticum
4'-fluoro-4-[4-(o-methoxyphenyl)-l-piperazinyl]-butyrophenone
f-^^>-C-CH2-CH2-CH2-CI hn^VQ —► F-<^>—c-ch2-ch2-ch2-n^n—C~\
° H3C0 \° H3C0
/"Chlor-4~fluorbutyrophenon t-(2-Melhoxy- I Fluanison phenylj-piperazin
404 F Fluanison - Fluazacort - Flubendazol
DOT1,53 (1965).
DAS 1 185 615 (Janssen; Anm. 25.3.1960; USA-Prior. 26.3.1959).
USP 2 997 472 (Janssen; ert. 22.8.1961; Prior. 26.3.1959).
D: Sedalande® (Delaiande) F: Sedalande® (Delalande)
Fluazacort 19888-56-3 Glucocorticoid
(Fluazacortenolacetat)
9-fluoro-ll^,21-dihydroxy-2'-methyl-5'|Sff-pregna-l,4-dieno[17,16-fl!]oxazole-3,20-dione 21-acetate
21-Acetoxy-3,20-dioxo-[t7a, I Fluazacort
16a-d]-2'-methyloxazoiin-
1,4,9 ni)-pregnatrien
taus 3f3-ftcetqxy-lt-hy<imy-(t7a,
)6e-d] -2'-mettiyloxazoiin-2Ci-<Jxo-5a-pregnar 1
DOT 12,396 (1976).
DAS 1 618613 (Gruppo Lepetit; Anm. 7.1.1967; GB-Prior. 11.1.1966,11.7.1966,29.9.1966). Ausgangsverbindung;
DBP 1 568 971 (Gruppo Lepetit; Anm. 23.12.1966; GB-Prior. 11.1.1966, 11.7.1966,29.9.1966). USP 3 624 077 (Gruppo Lepetit; ert. 30.11.1971; GB-Prior. 11.1.1966).
Ubersicht;
G. Nathanson et al., Steroids 13,365 (1969).
