Атлас заболеваний полости рта - Ланге Р.П.
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senker;
Antiarterioscleroticum
ethyl 2-(/>-chlorophenoxy)-2-methylpropionate
/—. НзС^ СНз
Cl—^ V-OH + jC=0 1- CHCI3 N*°H» Cl-f Ч-0-С-С00Н НзС СНз
4-Chior phenol Aceton Chloro- 2-(4-Chlorphenoxy)-iso-
form buttersaure
(Clofibrinsaure)
I CH3
c2H50H/HiS06 CI~Q~Q-C-COOC2H5 * РЎРќР·
Clofibrat
M. Julia et al., Bull Soc. Chim. Fr. 1956, 777.
USP 3 262 850 (TCI; ert. 26.7.1966; GB-Prior. 20.6.1958).
228 РЎ Clofibrat - Clofoctol
F: AtherolipВ® (Solac) ApoterinВ® A (Seiko)
ClaresanВ® (Sarbach) ArtehardВ® (Nissin)
Clofibral (Negma) AteculonВ® (Nippon Chemiphar^
Clofirem (Roland-Marie) AtelesВ® (Tokyo Hosei)
Dabical (I. S. H.) AtemarolВ® (Kowa Y.)
LipavJonВ® (Avion) AthebrateВ® (Kakenyaku)
Normolipol (Delagrange) AtherolateВ® (Fuji Zoki)
GB: Atromid SВ® (ICI) AtheromideВ® (Ono)
LiprinalВ® (Bristol) AtmolВ® (Taisho)
I: ArtevilВ® (Nuovo Cons. Sanit. Naz.) AtosterineВ® (Kanto)
AtrolenВ® (Firma) BinogracВ® (Zeria)
AtromidinВ® (Icp) BresitВ® (Toyo Jozo)
CitiflusВ® (Ct) CholenalВ® (Yamanouchi)
CloberatВ® (Negroni) CholestolВ® (Toho)
ClofibralВ® (Farmochimica Ital.) CholesrunВ® (Hokuriku)
ClofinitВ® (Gentili) ClarolВ® (Toyama)
FibramidВ® (Bonomelli-Hommel) ClobrateВ® (Chugai)
GeromidВ® (Zoja) ClobrenВ® (Morishita)
IpolipidВ® (Isnardi) ClofbateВ® (Mohan)
LipavilВ® (Sir) CliminonВ® (Meiji)
LipidiconВ® (Aristochimica) DelivaВ® (Nippon Kayaku)
LiporanВ® (Bristol Ital. Sud.) HyclorateВ® (Funay)
NibratolВ® (Lampugnani) HypocerolВ® (Fuso)
NormetВ® (Richter) LiprinalВ® (Banyu)
SclerovasalВ® (Iti) ' ScrobinВ® (Nikken)
J: AmotrilВ® (Sumitomo) USA: Atromid SВ® (Ayerst)
AupartonВ® (Samva)
Clofoctol 37693-01 -9 Chemotherapeuticum
(bei Atemweg-infektionen)
a-(2,4-dichlorophenyl)-4-(Ul,3,3,-tetramethylbutyl)-ocresol
ci
H3C-C-CH3 + РЎ1-РЎРќ2 CH2 H3C-C-CH3
CH3
4-(1A3,3-Tetra- 2,4-Dichlorbenzyl-
methylbutyl)- chlorid
phenol
OH
.CH2
РЅР·СЃ-СЃ-СЃРЅР· CH2
H3C--C-CH3
i
CH3 Clofoctol
DOT 15,171(1979). FP 1 602 455 (I. R. РЎ. E. B. A.; Anm. 21.8.1968; GB-Prior. 31.8.1967). USP 3 830 852 (I. R. РЎ. E. B. A.; ert. 20.8.1974; F-Prior. 18.8.1970). DOS 2 140765 (I.R. РЎ. E. B. A.; Anm. 13.8.1971; F-Prior. 18.8.1970).
F: OctofeneВ® (Debat)
Clometacin - Clomethiazol РЎ 229
Clometacin
25803-14-9
Antiphlogisticum;
Analgeticum
3-(j5-chlorobenzoyl)-6-methoxv-2 -methylindole-1 -acetic acid
H3C0^^-nВ°2
xx„„
4 “ Methoxy - 2 - nit ro-benzaldehyd
H3C-CH2-N02 /РЎРќР·РЎРћРћРќ /CHsCOONHi
^ХЧ-ГН=С —
РЎРќСЌ
ch=c-no2
1-(2-Nitro-4-methoxyphenyt)-
2-nitropropen
H3CC4^-^N
U>c*
6-Methoxy-2-methyl-
mdol
N,W-Oimethyi-4-chlor-
benzamid
H3CO.
H
II/
•CH3
в– O-В»
1. NaH/DMF
2 CI-CH2-COOCH3
2. Chloressigsaure-methylester
CH2-COOCH3 j CH2-C00H
H3C0'^i<^V'N 1 РєРѕРЅ/СЃРЅР·РћРЅ i H3^В°'v^;rvrr'N4
if л?—СНз гГ hci_ ! L if /)—1CH3
/в– O'В»
DBP 1 901167 (Roussel-Uclaf; Anm. 10.1.1969; F-Prior. 11.1.1968,10.4.1968,10.9.1968,11.9.1968, 10.12.1968).
F: Duperan* (Cassenne)
Clomethiazol
533-45-9
1867-58-9
Ethandisulfonat
Anticonvulsivum;
Hypnoticum;
Sedativum
5-(2-chloroethyl)-4-methylthiazole
nh2
i
Ss" NH^
Ammonium-
dithiocarbamat
CH-CH2-CH2-CJ
Cl
1,3-Dichlor-4-oxo-
pentan
РЎРќСЌ
-VL
HS"-\S>"CH2-CH2-Cl
5-(2-Chlorethyl)-2-mer-
capto-i-methyl-l^-thiazol
CH3 N-^ k^
4S^CH2-CH2-Cl Clomethiazol
CH-P 200 248 (Roche; 1937).
Sulfonate:
USP 3 031457 (R. Charonnat, J. Chareton, A. Boune; ert. 24.4.1962; F-Prior. 28.9.1955).
230 РЎ Clomethiazol - Clometocillin - Clomifen
Weitere Verfahren:
E. R. Buchman, J. Am. Chem. Soc. 58,1803 (1936).
Y. Sawa, T. Ishida, J. Pharm. Soc. Japan 76,337 (1956).
D: DistraneurinВ® (Astra Chemicals) GB: HeminevrinВ® (Astra)
F; HemineurineВ® (Debat)
Clometocillin
(Chlomethocillin)
1926-49-4
15433-28-0 K-Salz
Antibioticum
(3,4-dichloro-a-methoxybenzyl)pemcillin or 6-[2-(3,4-dichlorophenyl)-2-methoxyacetamido]-3,3-dimethyl-7-oxo-4-thia-l-azabicycIo[3.2.0]heptane-2-car boxy lie acid
3, U - Dichlor- a- methoxy-phenylessjgsaure
ch-c/
c/~^ 0CH3 ci
H H
HzNi-T V 3 /K2C03/Aceton/pH7-3/0GC
_COOH_^
S-Ammopenciltart-
saure
r-\ H H H
Cl-V \-CH~C-NH—t—j--svCH3
COOH
Clometocillin
USP 3007 920 (Recherche Industrie Therapeutiques; ert. 7.11.1961; GB-Prior. 28.10.1960). F: RixapenВ® (Smith Kline + French)
Clomifen
(Clomiphen)
911-45-5 50-41 -9
Cit rat
Gonadotropinstimulans;
Oestrogen
2-[/<-(2-chloro-1,2-diphcnylvmyl)phenoxy]triethylamine
H5c2.
N-РЎРЅРі-РЎРЅРі-РЎ!
HsC2
2-Diethylaminoetbyl-
chlorid
В»-o
4-Hydroxybenzo-
phenon
H5C2,
b
N-СЃРЅРі-РЎРќРі
H5C2
-В»-o
b
4-(2-Oiethylaminoethoxy)-benzo-
phenon
^-CHj-Cl/Mg РќР±РЎ2С‡ OH
—-* N—сНг-СНг-0—<' у-С-СНг-у V
BtrzylcHond / \—/ I \—/
bzw. Benzyimagnesium- H5C2
kJ
chlond
Clomifen - Clomipramin РЎ 231
USP 2 914 563 (Merreil; ert. 24.11.1959; Prior. 6.8.1957).
Anwendung:
Belg-P 782 321 (Richardson-Merrell; Anm. 19.4.1971).
D: DynericВ® (Merreil) I: ClomidВ® (Merreil)
F: ClomidВ® (JVferrefJ-Toraude) ProlifenВ® (Chiesi)
