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.., .. .: , 2008. 224 c.
ISBN 978-5-9704-0578-9
( ): pharmazeutischewirkstoffe1982.djvu
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A. Pedrazzoli et. al. Chim. Ther. 3,200 (1968).
Weiteres Verfahren:
GB-P 1539007 (С. M. Ind.; Laufzeit ab 26.10.1977; F-Prior. 8.11.1976). I: Parsal® (Midy)
Pasiniazid 2066-8Э-Э Tuberkulostaticum
isonicotinic acid hydrazide compound with 4-aminosalicylic acid
Isoniazifl + p-Aminosalicylsaure [a. S. 503) (s. S. 43)
CH-P 303 085 (Roche; Anm. 1952).
D: Dipasic® (Gewo) Pasiniazide Rolland (Hepatrol)
F: Paraniazide (Hepatrol) I: Dipasic® (Farmerid)
Pecazin 60-89-9 Neurolepticum
(Mepazin) 24360-97-2 Acetat
2975-36-2 Hydrochlorid
№[( 1 -mcthyi-3-pipendyl)methyl|phenothiazine
690 P Pecazin - Pecilocin - Pemolin
NaNH2 + Вг—СНг
Phenothia2in
CH3
Natrium- 3-Brommethyl-annid l-methylpiperidin
USP 2784 185 (Promonta; ert. 1957; D-Prior. 1953). D: Pacatal® (Promonta)
Pecilocin
19504-77-9
fungicides Antibioticum
* 2-pyrroIinone, l-(8-hydroxy-4-methyl-l-oxo-2,4,6-dodecatrienyl)-, [/?-(£,Z,£)-
CH)

&° HO^
Pecilocin
Aus Kulturlosurigen von Paecilomyces varioti Bainier var. anibioticus.
GB-P 866 425 (Japan Antibiotics Research Assoc.; Anm. 7.4.1959).
D: Supral® (Basotherm) GB: Variotin® (Leo)
F: Leofungine® (Leo) J: Variotin® (Nippon Kayaku)
PemOiin 2152-34-3 Psychoenergeticum (Phenoxazole)
2-amino-5-phenyl-2-oxazolin-4-one
_ OH ^NH
V V-CH-COOC2H5 + HzN-C7
4nh2
Mandelsaureethylester Guanidin
DOT 9,212(1973).
USP2 892753 (Boehringer Ing.; ert. 30.6.1959; Prior. 26.2.1957).
D: Stimul® (Nadrol) Ronyl®(Rona)
Tradon® (Beiersdorf) I: Sigmadyn® (Spemsa)
F: Deltamine® (Aron) J: Antimeran® (Nichiiko)
GB; Cylert®(Abbolt) USA: Cyiert®(Abbott) Kethamed® (Medo)
0VVH!
o^NH !
Penbutolol - Penfluridol P 691
Penbutolol 38363-40-5 Betablocker
l-(ferf-butylamino)-3-(o-cyclopentylphenoxy)-2-propanol
A
а-снг"
2-Cyclopentyl - Eptchlorhydrtn phenol
.O-CHz-^Cj
1,2-Ероху-3-{2-сус1о-pentylphenoxy)-propan
1. H2N-C(CH3)3/C2M50h
2. Racematspaltung mit o-(-l-Mandelsaure 1 terf-Butylamin
OH
I
CH2-CH-CH2-NH-C(CH3}3
DOF1,494 (1976); 2,706 (1977); 3, 780 (1978). SA-P687915 (Hoechst; Anm. 15.11.1968;D-Prior. 8.12.1967). Weiteres Verfahren; DOS 2 503 222 (Boehringer Mannh.; Anm. 27.1.1975).
D: Betapressin® (Hoechst) Betasemid® (Hoechst)-Komb.
Penfluridol 26864-56-2 Neurolepticum
4-(4-chloro-a.a,a-trifluora-m-tolyl)-l-[4,4-bis(p-fluorophenyl)butyl]-4-piperidinol
CF3
НзСООС -
=-0 + BrMg—<f~y~ Cl -► H3COOC - f/ X---N
*»-Oxopiperidin-1- 4-Chlor-3-tri-
carbonsauremethyl- fliiormethyl-phenyl- Ct
ester magnesiumbromid
b2w. 5-8rom-2-chlor-trifluormethyl benzol
Cl
F—CH —CH,-CH;—CH3—Cl/Na2C03

_F_
4,4-Bis-(4-fluorphenyl) -butyi-chiorid
4-(i-Chlor-3-trifluor =
methylphenyl)-4-
hydroxypiperidm
692 P Penfluridol - Pengitoxin
USP 3 575 990 (Janssen; ert. 20.4.1971; Anm. 3.9.1969).
DOS 2040231 (Janssen; Anm. 13.8.1970; USA-Prior. 3.9.1969). Alternativ-Synthese:
FP-Anm. 2 161 007 (Janssen; Anm. 23.11.1972; J-Prior. 25.11.1971).
D: Semap® (Janssen)
F: Semap® (Le Brun)
Pengitoxin
7242-04-8
Herzglycosid
gitoxin pentaacetate
(H3C-COI2O
Acetanhydrid
DBP 1 252 202 (Deutsche Akad. derWissenschaften; Anm. 4.11.1963). GB-P 1043029 (Arzneimittelwerk Dresden; Anm. 15.6.1965).
J-Anm. 6982 ('60) (Shionogi; Anm. 15.6.1960).
D: Camacid-Cor® (TAD)
Cordoval® (Tempelhof)
D-Penicillamin P 693
D-Penicillamin
D-3-mercaptovaline
52-67-5 2219-30-9
Hydrochlorid
Antidot bei Schwermetall-vergiftungen Therapeuticum gegen Morbus Wilson und Rheumatoide Arthritis
Aus Penicillin G HOOC
H cAS-W~NH “ CO 'CH2 - C6Hs ЙН
Benzylpenieillin (Penicillin G)
HOOC
н’с s'^'ch2-nh- со-снг-с6н5
Peniltosaure
b
‘ Benzylpenicidin + H;N~ NH—
Phenylhydrazin
HOOq
NaOH <f00H
н3с
HgCl2 У HCI
‘g-i—CH — NH — CO — CH2"“ CqHs Q«tcksilb«t{ li \-
Pemcillosaure
D-Per>ciUamm-Hg2+- Komplex
Totalsynthetisch
HsCs-CH2-C6-NH
H
2 -Phenyl - Д-phenylacetamido - 3-pyrazotin-5-on
CH3
I
Н3С-С-СН-СООН I I
HS nh2
O-Penicjllamin
+ Q - PeniciUamm
CHO
I
2 НзС-СН +■ S + NH3 -
СНз
(sobutanal Schwetel Ammoniak
^зЛ-сн-снз
СНэ
5J5-Dimethyl-2-iso-
propyl-^3-thiazotin
Cyan-
wasserstoff
H3C
H3C
£
NH
S^CH-CHa
CH3
НэС.
нэс
.As^CH-
СНз
СНЗ
HOOC-CH —NH?
I
НзС-С—SH • HCI
СНз
D,l.-PeniciUamin-
Hydrochlorid
HOOC
нзс^~^сн,
H3C S CH3
2,2,5,5-Tetra-
methyttfiiazoUdin-
4-carbonsaure
HCoONa/fHjC—Coho
— I
NaUiurr-1 Acetanhydnd format I
HOOC,
нэс
H3C
CHO
CH3
CH3
D,L '3-Form/t-2,2,5,5-tetramethyi-thiazolidin-4-carbonsaure
1 Racematspaltung mit (-)-Pseudororephednn oder (-)-Norephedrtn 2. HCJ
О-3-Formyl-
2,2,5,5-tetramethyl-
thiazolidin-Л-
carbonsaure
□-PemoUamtn • HCI
D-Penicillamm
694 P D-Penicillamin - Penimepicyclin und Pipacyclin
DOT 9, 302(1973).
a GB-P 854339 (DistillersCo.; Anm. 22.8.1957; Laufzeit ab 23.7.1958). USP 3 281461 (Squibb; ert. 25.10.1966; Anm. 7.11.1963).
DAS 2 114 329 (Heyl & Co., Anm. 24.3.1971).
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