- ..
ISBN 978-5-9704-0578-9
( ):
Dimethyl-sulfat
4~Ethyl-4-phenyl-
hydantoin
Mephenytoin
Ehrhart-Ruschig, Bd. 1,196,
DRP 309 508 (Chem. Fabrik von Heyden; Anm. 1914). FP 769 667 (Sandoz; 1934).
D; Mesantoin® (Sandoz) F: Sedantoinal® (Sandoz) GB; Mesontoin® (Sandoz)
I: Mesantoina® (Sandoz) USA: Mesantoin® (Sandoz)
Mepitiostan
21362-69-6
Anti-Oestrogen
cyclopentanone 2a,3a-epithio-5a-androstan-17/?-yl methyl acetal
ОСНз
А. НэС-^-503Н/
'-' о - Toluol suit on saur*/1
IHjCJjC-OH p-Toluolsulf orsaufe/fer<-Butanol
1-Methoxy-
cyclcpenten
558 M Mepitiostan - Mepivacain - Meprednison
DOF3, 311 (1978); 4, 306 (1979).
DBP 1 668 659 (Shionogi; Anm. 27.1.1968; J-Prior. 28.1.1967). J: Thioderon® (Shionogi)
Mepivacain
22801-44-1
16452-56-5 Hydrochlorid
Lokalanastheticum
(±)-l-methyl-2',6'-pipecoloxylidide
СНз
NHs
CH3
2,5-Dimethyl-
anilin
H5C2—‘МдВг
Ethylmagnesium-
bromid
CH3
({ %—NH-MgBr CH3
H5C2OOC-<f) N—'
Нз(/
1-Methylpipendm-
2-carbonsaure-ethylester
CH3
C^-nh-co43
СНз н3</
Mepivacain
сн3
Q-TS
СНз
a-Picolinsaure-2J6-xylidid (vgf. Bupivacain-Synthese, s. S. 124)
CH3
СНз H
Pipecolinsaure-2,6-)(ylidid
(CH;Q)r, /Hz/Pd-C
Paraform-
aldehyd
Mepivacain
a USP 2 799 679 (AB Bofors; ert. 1957; S-Prior. 1955).
B. af Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957).
H. Rinderknecht, Helv. Chim. Acta 42,1324 (1959). b DOS 2 726 200 (Bofors; Anm. 10.6.1977; S-Prior. 22.6.1976).
USP 4110 331 (Bofors; ert. 29.8.1978; S-Prior. 22.6.1976).
Analogverfahren mit Methylierung vor Hydrierung des Pyridin-Kerns:
GB-P 826 668 (Crookes Labs.; Anm. 1955). d-( — )-Mepivacain:
DOS 2 259 517 (Bofors; Anm. 5.12.1972; USA-Prior. 6.12.1971).
D: Meaverin® (Woelm Pharma) I: Carbocaina® (Pierrel)
Mepivastesin® (Espe) J: Carbocain® (Yoshitomi)
Scandicain® (ICN) USA: Carbocaine® (Winthrop)
Meprednison 1247-42-3
17,21-dihydroxy-16/5-methylpregna-1,4-diene-3,11,20-trione
Glucocorticoid
Meprednison - Meprobamat M 559
H3C-C0-0'
За-Acetoxy-ll, 20-dioxo-16-pregnen
1 CHjN2 2. A 1. Diaza-methan
H3C-CO-O'
H3C
1 H2 /Pd—CaCOj
2 IHjC-COIjO/HClOt
04.
2 AcetanhyOrid /Per-cfilorsaure
3 Perbenzoesaure
2. ШКОСОСэ H3C C0 0 CH2.
0^-y.Q
1. Bfoni 3. N-Brom-succinimid
2 H-C
40
3 КНСО?;СНзОН/НгО _
Meprednison
HO-CH2.
Se02/H5C2-C-CH3
oder xikrobiologisch mit Bacillus Sphaeneus var fusiformis A T.C С 70S5 Setendioxid / tert-Amylalkohol
Meprednison
16/?-Melhylcortison
USP 3 164618 (Schering Corp., ert. 5.1.1965; Prior. 23.7.1957, 8.5.1958).
D. Taub et al., J. Am. Chem. Soc. 82,4012 (1960); 80,4435 (1958).
E. P. Oliveto et al., J. Am. Chem. Soc. 80,4428 (1958). Ausgangsverbindung fur a:
H. L. Slates, N. L. Wandler, J. Org. Chem. 22,498 (1957).
USP 2 671794 (Glidden; ert. 1954; Prior. 1950,1949).
Weitere Verfahren: aus Hecogenin:
G. B. Nathansohn et al., Experientia 17,448 (1961). aus Sitosterin:
USP 4 041055 (Upjohn; ert. 9.8.1977; Prior. 17.11.1975).
F: Betalone® (Lepetit) I: Corti-Bi (Sidus)
USA: Betapai® (Parke Davis) Betapred® (Schering)
Meprobamat 57-53-4
2-methyl-2-propyl-l,3-propanediol dicarbamate
Tranquilizer
560 M Meprobamat - Meproscillarin
нэС н3с сн2-он
СН-СНО ♦ 2 СН20 -»■ /С
Н7Сз н7Сз СН2-ОН
2-Methyl- Form- 2-Methyl-2-propyl-
valeraldehyd aldehyd propan-1,3-dioi
I.COClj 2 NH,
H3cv CH2-O-CO-NH2 c'
H7cf 4ch2-o-co-nh2
Meprobamat
USP2724720 (Carter Products; ert. 1955;Prior. 1953).
B. J. Ludwig, E. C. Piech. J. Am. Chem. Soc. 73,5779 (1951).
D: Aneural® (Wyeth)
Cyrpon® (Tropon)
Dabrobamat® (Dabrowski)
Dystoid® (Makara)
Meprobamat Saar (Chephasaar) Meprocompren® (Cascan)
Meprosa® (Chemipharm)
Miltaun® (Mack)
Miltaunetten (Mack)
Restenil® (Kabi)
Urbilat (Hor-Fer-Vit)
F: Equanil® (CKn-Comar-Byla)
Libiolan® (Knoll France)
Meprobamate Richard (Richard) Procalmadiol Adrian(Adrian-Marinier) Procalmadiol Allard (Allard) Procalmadiol Toraude (Merrell-Toraude) zahlreiche Komb.-Praparate GB: Equanil® (Wyeth)
Mepavlon® (ICI)
Miltown® (Wallace Labs.)
Tised® (Ticen)
I: Distonium® (Lepetit)-Komb.
Edenai® (Wassermann)
Meprodiol® (Pirri)
Meprodiol® B6 (Pirri)-Komb.
Miltaun® (Cyanamid)
Oasil® (Simes)
Perequil® (Lepetit)
Quanil® (Wyeth)
Quanitrate® (Wyeth)-Komb.
Quietidon® (Pharma Farm. Spec.)
Sedabik® (Byk Gulden)-Komb.
Sedoquil® (Libra)
Selene® (Biomedica)
Stensolo® (Salfa)
J: Atraxin® (Daiichi)
Erina® (Sumitomo)
Harmonin® (Yoshitomi)
Mepron® (Choseido)
Mepron® (Kanto)
Xalogen® (Ono)
USA: Equanil® (Wyeth)
Kesso-Bamate® (McKesson)
Mepriam™ (Lemmon)
Meprobamate® (Parke-Davis; Philips Roxane) Meprospan® (Wallace)
Meprotabs® (Wallace)
Miltown® (Wallace)
SK-Bamate™ (Smith Kline & French) Generic-Praparate
Meproscillarin
(Rambufasid;
Meproscillaridin)
33396-37-1
Herzglycosid
3/i-[(6-deoxy-4-0-methyl-a-L-mannopyranosyl)oxy]- 14-hydroxybufa-4,20.22-trienolide
Proscillaridin
(s. S. 777)
OC2H5
+ H-C-OC2H5 I
OC2H5
