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.., .. .: , 2008. 224 c.
ISBN 978-5-9704-0578-9
( ): pharmazeutischewirkstoffe1982.djvu
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Lyndiol® (Organon)-Komb. Noracycline® (Gba)-Komb. Orgaluton® (Organon)-Komb. OrgamerriJ® (Organon)
Ovanon® (Organon)-Komb. Ovariostat® (Organon)-Komb. Lyndiol® (Organon)-Komb. Lyndiol® (Organon-Sankyo)-Komb.
534 М Mafenid und Sulfatolamid - Maprotilin
Mafenid und Sulfatolamid
138-39-6
1161-88-2
Matenid
Sulfatolamid
Chemotherapeuticum
a-amino-p-toluenesulfonamide
l-sulfanilyl-2-thiourea derivative of a-amino-p-toluene-sulfonamide
H3C—CO—NH —CH2 A/-Benzylacetamid
1 C1S03H 2. NH3
i Chtor-sulfonsaure
-ch2^>so2-nh2
H3C-CO—NH
4-{Acetamidomethyl )-benzol-sulfonamid
h2n-ch2^^so2
Mafenid
ы~0>-
SOj—NH—C
A'-U-Aminophenylsutfonyll-
thioharnstoft
(Su/fan/iyltrooharnstoff]
DOT 5, 132 (1969).
Mafenid:
DRP 726386 (I.G. Farben; Anm. 1939).
USP 2288531 (Winthrop; ert. 1942; D-Prior. 1939). Sulfanilylthiohamstoff:
FP 913920 (Rhone-Poulenc; Anm, 1942).
Sulfatolamid:
USP 2696454 (Schenley Ind.; ert. 1954; CH-Prior. 1949). DBP 836350 (Bayer; Anm. 1944).
D: Marbaletten® (Bayer)-Sulfatolamid Napaltan® (Winthrop)-Mafenid F: Anafluose® (Guillaumin et Hales)-Mafenid-Komb.
GB: Sulfamylon® (Winthrop)-Mafenid Sulfomyl® (Winthrop)
J: Paramenyl® (Takeda)
USA: Sulfamylon® (Winthrop)-Mafenid
Maprotilin
10262-69-8
10347-81-6 Hydrochlorid
Antidepressivum
A/-methyl-9,10-ethanoanthracene-9(10H)-propylamine
ch2-ch2-cooh
Lithium-
alanat
3-{9-Anthryl)-
propionsaure
ch2-ch2-ch2-oh
9-(3-Hydroxypropyl)-
anthracen
SOCl}
Thonyl-
ehlorid
ch2-ch2-ch2-ci
CH2-CH2-CH2-NH-CH3
9- [3-Methylaminopropyl ] -anthracen
H2C=CH2
50 atu /24 Stdr /I50CC
ch2-ch2-ch2-nh-ch3
Maprotilin
Maprotilin - Mazaticol - Mazindol M 535
CQO
CH2~CH2-COOH
3-(9-Anthryl)-
propionsaure
H;C=CH2/DMF _ Ethylen
CO-Cl 1 I CO-Cl 2. CHjNH;
1 Oxalylchlond 2. Methytamiri
ch2-ch2-co-nh-ch3
lithium-alanat
Maprotilin
DOT 9,221, 323 (1973).
DBP 1513691 (Ciba; Anm. 16.12.1965; CH-Prior. 23.12.1964).
CH-P 467237 (Ciba; Anm. 23.12.1964).
CH-P467747 (Ciba; Anm. 23.12.1964).
D: Ludiomil® (Ciba) GB: Ludiomil® (Ciba-Geigy)
F: Ludiomil® (Ciba) I: Ludiomil® (Geigy)
Mazaticol 42024-98-6 , Antiparkinsonmittel;
38738-5Э-Э Hydrochlorid Muskelrelaxans
6,6,9-trimethyl-9-azabicyclo[3.3.1]non-3/8-yl di-2-thienylglycolate
,ch3
?H 0
i> -< , ,44
OH
Oi-2-thienylglykot- бД9-Тпте1Му1-9- Mazaticol
sauremethylester azabicycio [3 31 j - ‘
nonan-3/3-ol
DOT 13, 72(1977).
DOS2Q26462 (Tanabe Seiyaku; Anm. 29.5.1970; J-Prior. 8.10,1969). USP3673 195 (Tanabe Seiyaku; ert. 27.6.1972; Prior. 25.5.1970).
N. Yoneda et al., Chem. Pharm. Bull 20,476 (1972).
J: Pentona® (Tanabe)
Mazi ndol 22232-71 -9 Appetitziigler
5-(p'-chloropheny])-2,5-dihydro-3W-imidazo[2,l-a]-isoindoI-5-ol
536 М Mazindol - Mebendazol
ос;.
H2N-CH2-CH2-NH2
о
JMN /=* IN
Он
'"i нэс $0зС1 y Py,,d,n j-J --
2-{6-Chlorphenyl)- Ethylendiamin benzoesaure
N—v c-o
i'-Ch(or-2-(2-irrii-
dazolinyU-benzophenon
Mazindol
DOT 10,24 (1974).
DOS 1 770030 (Sandoz; Anm. 22.3.1968; USA-Prior. 23.3.1967).
USP 3 597 445 (Sandoz-Wander; ert. 3.8.1971; Anm. 19.6.1968).
USP 3 763 178 (American Home Products; ert. 2.10.1973; Anm. 5.9.1968; Prior. 15.9.1965, 2.9.1966, 14.3.1967).
Alternati v-Synthesen:
DOS 1795 105 (Sandoz; Anm. 10.8.1968; USA-Prior. 15.8.1967, 3.5.1968).
DOS 1814 540 (Sandoz; Anm. 12.12.1968; USA-Prior. 18.12.1967, 23.7.1968).
DOS 1930488 (Sandoz; Anm. 16.6.1969; USA-Prior. 19.6.1968).
D: Teronac® (Wander) USA: Sanorex® (Sandoz)
GB: Teronac® (Wander)
Mebendazol 31431-39-7 Anthelminticum
methyl 5-benzoyl-2-benzimidazolecarbamate
4-Chtorbenzophenon 4-Chtor-3-mtrobenzcphenon 4-Amino-3-nitrobenzophenon
3,6-Diaminobenzo-
phenon
* и
Mebendazol - Mebeverin M 537
H3CS
Ji = N —СООСНэ
H2N
S-Methylisothioharnstoff-JV-
carbonsauremethylester
И , (§ CHjCOONa^ OLcJOO'NH'COOCH1
Mebendazol
DBP 2029637 (Janssen; Anm. 16.6.1970; USA-Prior. 20.6.1969).
USP 3 657 267 (Janssen; ert. 18.4.1972; Prior. 20.6.1969).
D: Vermox® (Janssen) I: Vermox® (Janssen)
GB: Vermox® (Janssen) USA: Vermox®(Ortho)
H3cs
h2n
H2SO<. + CI-COOCH3
NaOH,pH 8_
S- Methyfisothioharnstoff-sutfat
Chlorametsen>
sauremethylester
Mebeverin 3625-06-7 Spasmolyticum
2753-45-9 Hydrochloric!
4-[ethyl(/>-methoxy-a-methylphenethyl)ammo]butyl veratrate
H2N-C,H5 + С-СН,—/VoCH, —-* CH~CH2-(\ /V-OCH3
t^ '—f BtTns\®>nsaur м^у(еь\ет -chlorid
Ethylamin (4-Met hoxy phenyl) - ace ton 2-Eihylamino-1-U-methoxy-
phenyD-propan
;C2H5 ртНь
H5C2OOC-CH2-CH2-CO-N uaih‘ , ho-ch2-ch2-ch2-ch2-n
\h-CH2-<Q>-OCH3 ST 4CH-CH2HQbOCH3
CHq CH3
.C2Hs
H5C2OOC-CHi-CH2-CO-CI
h3co-^7^-co-ci
H3C0
H3C0
H3C0 “CH2-CH2-CH 2-ch2-N4
3,i-DimetlV5*y-E>?nioylcMorid
IVeratrumsaure-cMond) Meh*varir
DOT 3,143(1967).
DBP 1 126 889 (N. V. Philips; Anm. 20.11.1958, NL-Prior. 23.11.1957). Alternativ-Verfahren:
GB-P 1009082 (N. V. Philips; Anm. 19.10.1961; NL-Prior. 22.10.1960).
D: Duspatal® (Thomae/Duphar) F: Duspatalin® (Duphar)
GB: Colofac® (Duphar)
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