booksshare.net -> -> -> .. -> " " -> 230

- ..

.. , 1962. 711 c.
( ): pharmazeutischewirkstoffe1982.djvu
<< 1 .. 224 225 226 227 228 229 < 230 > 231 232 233 234 235 236 .. 345 >>

D: Helmex®-Roerig (Pfizer) J: Combantrin® (Pfizer)
F: Combantrin® (Pfizer) USA: Antiminth® (Roerig)
I: Combantrin® (Pfizer) Combantrin® (Pfizer)
Pyrazinamid 98-96-4 Tuberkulostaticum
pyrazinecarboxamide
^ ^ NH3/CH30h
^Лс-0СНз ‘
II 0
Pyrazin-2-carbon-sauremethylester
DRP 632257 (E. Merck; 1934). S. A. Hall et al., J. Am. Chem. Soc. 62,664 (1940).
D: Pyrafat® (Saarstickstoff-Fatol) J: Pyramide® (Sankyo)
GB: Zinamide® (Merck Sharp & Dohme) USA: Pyrazinamide (Lederle)
I: Piraldina® (Bracco)
Pyrazinamid
Pyridinolcarbamat 1882-26-4 Antiarterioskleroticum
* carbamic acid, methyl-,2,6-pyridinediyldimethylene ester
H°-CH2 N CH2-0H 2 H3C —N = C= 0 + ILJ
Methylisocyanat 2,6- Dihydroxymethylpyridin [Bis-2,5-(hydroxymethyU-pyridin ]
H3C-NH
NH-CH3 !
//
c - 0 -ch2^n^ch2 - 0 - c.
xf‘'
Pyridinolcarbamat
Ausgangsprodukt:
HOOC M COOH
XT
Pyridm-2,6-dicarbon-
saure
(Dipicolinsaure)
но-снг ы^сн2-он
XJ
788 P Pyridinolcarbamat - Pyridofyllin
ь
0
нзс^гуснз ^СНзСООН^ НзС^у^з (HjC.CO]2^ H3C^yCH2-0-C0-CH3
2,6-Luttdin
О
НзС XH2-O-CO-CH3
^ ^ IH3C-CQ);0
и
H3C-C0-0-CH2^yCH2-0-C0-CH3 H,o/|HCI; Dd«. снзонфаон! HO-CH,yi vCH2-0H B/s-2,6-{acetoxymethyl )-pyndin
e
НзС'^уСН3 Cl; /H;SOt / [ *ZQ-blS-l.obulytonil„l] ; Cl ~ СН2_^|^СН2-Cl
2,6-Lutidin 2,6-Bis-(chlormethy[]-pyridin
Н20/ [h*!
НО-СН2._|^ ,CH2-OH
XI
FP 1396 624 (M. Inoue; Anm. 13.4.1964; J-Prior. 13.4.1963).
Oe-P 258 953 (M. Inoue; Anm. 13.4.1964; J-Prior. 13.4.1963).
Oe-P258954 (M. Inoue;Anm. 13.4.1964; J-Prior. 13.4.1963).
Oe-P 258 955 (M. Inoue; Anm. 8.11.1965).
Alternativ-Verfahren [aus Bis-2,6-(hydroxymethyl)-pyridin und iV,iV'-Dimethylharnstoff ]: DOS 2 263 812 (Rocador S. A.; Anm. 28.12.1972; E-Prior. 28.12.1971).
■/j- und y2-Modifikationen:
DOS 2 702 772 (Richter Gedeon; Anm. 24.1.1977; H-Prior. 24.1.1976).
GB-P 1 548 334 (Richter Gedeon; Anm. 21.1.1977; H-Prior. 24.1.1976). Bis-2,6-(hydroxymethyl)-pyridin:
a FP 1396 624 (M. Inoue; Anm. 13.4.1964; J-Prior. 13.4.1963). b V. Bockelheide u. W. J. Linn, J. Am. Chem. Soc. 76,1286 (1954). с FP 1394 362 (Merck & Co.; Anm. 31.3.1964; USA-Prior. 2.4.1963).
Weitere Verfahren:
DAS 2 460039 (Richter Gedeon; Anm. 19.12.1974; H-Prior. 29.12.1973).
DAS 2614400 (Richter Gedeon; Anm. 2.4.1976; H-Prior. 2.4.1975).
F: Angioxine® (Roussel) Movecil® (Erba)
I: Angiovital® (Ism) Ravenil® (Caber)
Angioxil® (Firma) Vasagin® (Sidus)
Aterofal® (Nativelle) Vasapril® (Cifa)
A lover® (Oti) Vasocil® (Magis)
Cicloven® (Agips) J: Anginin® (Banyu)
Pyridofyllin 53403-97-7 Coronarvasodilatator
pyridoxol salt of 7-(2-hydroxyethyl)theophylline hydrogen sulfate ester
Pyridofyllin-Pyridostigmin-bromid- Pyridoxin P 789
О CH2-CH2-OH
I
I
CH3
Etofyllin (s. S. 381)
0 CH2-CH2-O-SO3H
cnct3 /aso^H НзС'^н'7г'Мч
1
CH3
Chlorsulfonsaure
0-{7-Theophy[linylethyU-schwefelsaure
’Й1
но у снг-он CH; —OH Pyndoxin
^nA.n
1 JC>
O^N^N
CH2-CH2-O-SO3H
CH3
H3C___N.
НО у CH 2-OH CH2-OH
PyridofylUn
FP-M 828 (J. Debarge; Anm. 23.12.1960). F: Atherophylline (Merrell)
Pyridostigmin-bromid
101-26-8
3-hydroxy-l-methylpyridinium bromide dimethylcarbamate
Parasympathico-
mimeticum
(Cholinesterase-
blocker);
Antimyasthenicum;
Vagotonicum
Qr°
Cl —CO—N
СГ°
CHa
CH3
3-Hydroxy-
p/ridin
Dimethylamino-
carbonylchlorid
3-(Dimethy(amtno-
carbonytoxy)-pyridin
CH-P 246834 (Roche; Anm. 1945).
USP 2 572 579 (Roche; ert. 1951; CH-Prior. 1945).
ГУ
4N <
I
CH3
,0-CO-N
\
CH,
Pyridostigmin-bromid
D: Mestinon® (Roche)
F: Mestinon® (Roche)
GB: Mestinon®(Roche)
I: Mestinon® (Roche)
J: Mestinon® (Nippon Roche) USA: Mestinon® (Roche) Regonol® (Organon)
Pyridoxin
(Vitamin B6)
58-56-0
Vitamin
3-hydroxy-4,5-di(hydroxymethyl)-2-methylpyridine
790 P Pyridoxin
a Merck * Co.:
ЖС-СН-СООН
I
NH2
D.L'Alanin
CjHsOH/HCl
H3C-CH-COOC2Hs • HCl NH2
0,1-Alanmethylester-Hydrochlorid
H3C-CH-COOC2H5
NH-CHO
N- Formyl - D, L-alanm -ethylester
H3C OC2H5
У=(
Ncs.0
^0 CH, -1 n y~ CH-CH3;180°C
2. MCI
1. 2-Isopropyl-4,7'dihydro-1,3-dioxepin (Acetal aus Isobutyr-5-EthOXy-i-methyl- aldehyd * 2-Buten-i,4-diol oxazol
(4-Methyl-5-ethoxy-oxazol)
I CH2— OH
1 HO i CH2-0H
I НзС'Чг
Pyridoxin I
h3cn
C-CH-COOC2H5
1
0 Cl
a-CMoracetessigsaure-
ethyiester
H3C COOC2H5
4-Methyloxazol-
5-carbonsaure-ethylester
0
H3W~
U^.0
5-Methyloxazol-
5-carbonsaure-
anrnd
HaC^CTN
'=w
5~Cyano-4-methyloxa-zo( K-Me-thyl-5-cya-nooxazol)
/-О СНз
I X ,190°C 4-^o ch3
2,2—Dimethyl-4,7— dihydrQ-l,3-dioxe-pin (Ketai aus Acetort * 2-Buten-1 4-dml}
H3C
.О-Д-'СНз 0
НзС'
Pyridoxin
H3C COOC2H5
H
1 NaOH 2. Д
4 - Methyloxazol- 5-carbonsaureethylester (vgl. unter b )
H3C,
я
SO2 CH3
4-Methyl-
oxazol
3- Methylsuifonyl- 2,S-dihydrofuran fdurch Addition von Metrtansuifonyl-Sromid an 2,5-Dihyarofuran und nachfolgend* НВг-Abspaltung mit NaOH)
H3C N
<< 1 .. 224 225 226 227 228 229 < 230 > 231 232 233 234 235 236 .. 345 >>

c1c0fc952cf0704ad12d6af2ad3bf47e03017fed

, ?
2009 BooksShare.
.
Rambler's Top100

c1c0fc952cf0704ad12d6af2ad3bf47e03017fed