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H?N
C-H
o'"
Formamid
USP 2 578 847 (ICI.; ert. 1951; GB-Prior. 1949). DBP 843 413 (ICI.; Anm. 1950; GB-Prior. 1949).
D: Liskatin® (Desitin)
Mylepsinum® (ICI-Pharma)
Resimatil® (Labaz)
F; Mysoline® (ICI-Pharma)
GB: Mysoline® (ICI)
I: Mysoline®(Icpharma)
J: Mysoline® (Dainippon; Marupi) Primron® (Fujinaga)
USA: Mysoline® (Ayerst)
Probenecid
57-66-9
Gichtmittel
/?-(dipropylsulfamoyl)benzoic acid
H7C3^
CI-S02
H7C3
Dipropyl- A-Carboxybenzolsulfonyl-amin chlorid
USP 2 608 507 (Sharp & Dohme; ert. 1952; Prior. 1949).
I:
COOH!
Probenecid
D: Benemid® (Sharp & Dohme)
F: Benemide® (Theraplix)
Prototapen (Bristol)-Komb.
GB: Benemid® (Merck Sharp & Dohme)
Colhenemid® (Merck Sharp & Dohme)-Komb.
Benemid® (Merck Sharp & Dohme) Solpurin® (Salfa)
Uroben®(Mitim)
Urocid® {1st. Chim. Intern.)
J: Benecid® (Kaken)
Probenemid® (Merck-Banyu)
USA: Benemid® (Merck Sharp & Dohme)
762 P Probucol - Procain
Probucol
23288-49-5
Antiarterioskleroticum (Cholesterin- und Lipidsenker)
acetone bis(3,5-di-ierr-butyl-4-hydroxyphenyl)-mercaptole
(H3O3C
2 ho-/3-sh
(H3O3C
2j6-Di-^erf-butyl-
4-mercaptophenol
CH3
CH3
(H303C
HO
(H303C
C(CH3h CH3 / 33
У V-s-c-s—oh
CH3 Probucol
C[CH3l3
DOF2,128(1977).
DOT 14, 34 (1978).
USP 3 862 332 (Dow; ert. 21.1.1975; Prior. 11.5.1967,19.11.1969).
DBP 1767443 (Dow; Anm. 10.5.1968; USA-Prior. 11.5.1967). Ausgangsprodukt:
USP 3 129 262 (Consolidation Coal Comp.; ert. 14.4.1964; Anm. 8.10.1962).
D: Lorelco® (Dow)
Lurselle® (Merreil)
USA: Lorelco® (Dow)
Procain
59-46-1
51 -05-8 Hydrochlorid
Lokalanastheticum;
Analgeticum;
Geriatricum
2-diethylami noethyl p-aminobenzoate
H2N
4>
COOC2H5
4'Aminobenzoesaure-
ettiylester
ho-ch2~ch2-n
4c2h5
2-Diethytaminoethanol
[NaOC2Ms]
| H2N-^-C0-0-CH2-CH2-n'
c2H5
c2H5;
02N-^ у—COOH £-Nitrobenzoesaure
02N
CO-Cl
4-Nitrobenzoy(ctiland
02N—$ ^
HO-CH2-CH?-N(C2Hs)2
2-Oiethy(annnoetharol
C*H5
C0-0“CH2-CH2—N
C2H5
A. Eichhorn, E. Uhlfelder, Justus Liebigs Ann. Chem. 371, 125, 131, 142,162 (1909). DRP 179 627 (Farbwerke Hoechst; Anm. 1904).
DRP 180291 (Farbwerke Hoechst; Anm. 1905).
DRP 194 748 (Farbwerke Hoechst; Anm. 1905).
Salz mit Phenylbutazon (Antiphlogisticum):
DAS 2 055 853 (Dr. Voigt; Anm. 13.11.1970).
Procain - Procainamid - Procarbazin P 763
D: Causat® (Reiss)-Komb.
Depot-Impletol® (Bayer)-Komb.
Dodecatol® (Heyl)-Komb.
Eupragin® (Thilo)-Komb.
Gerigoa depot® (Scheurich)-Komb.
Impletol® (Bayer)-Komb.
K.H. 3 Geriatricum Schwarzhaupt®(Schwarz-haupt)-Komb.
Melcain® (ICN)-Komb.
Neurischian® (Krewel)-Komb.
Novocain® (Hoechst) Pasconeural-Injektopas® (Pascoe)-Komb. Recaps®-Depot (Melusin)-Komb.
Sensiotin® cum Procain (Steigerwald)-Komb. zahlreiche Komb.-Praparate
F: Novitan® (Deglaude)
Procaine Biostabilex (Biostabilex) Procaine Lavoisier (Chaix et du Marais) zahlreiche Komb.-Praparate I: Anestetico® Vis (Vis)
Gerovital® H 3 (Schoum)
Novocaina® (Hoechst)
Recorcaina® (Recordati) u. Komb.-Praparate J: Bancain® (Banyu)
Omnicain® (Daiichi)
USA: Adrocaine® (Parke-Davis)
Novocain® (Winthrop)
Procaine Hydrochloride (Abbott)
Procainamid
51-06-9
614-39-1 Hydrochlorid
Antiarrhythmicum
p-amino-JV-[2-(diethylamino)ethyl]benzamide
03N
~O~c0-ci
P2H5
h2n-ch2-ch2-n
C2H5
4-Nitrobenzoyichtorid tyW-Diethyiethylendiamm
02N-O^'
P2H5
CO-NH-CH2-CH2~N
g2h5
C2H5
CO-NH-CH2-CHj-N
C2H5j
Procainamid
Ehrhart-Ruschig II, 38.
R. Baltzy et al., J. Am. Chem. Soc. 64,2231 (1942).
M. Y. Yamaiaki et al., J. Pharm. Soc. Japan 73,294 (1953).
D: Coritrat® (Nordmark)-Komb. Novocamid® (Hoechst)
Rhythmochin® I/II (Promonta)-Komb. F: Pronestyl® (Squibb)
GB: Pronestyl® (Squibb)
I: Procainamide (Simes)
J: Amisalin® (Daiichi)
USA: Procainamide Hydrochloride (Parke-Davis) Procamide (Amfre-Grant)
Pronestyl® (Squibb)
PrOCarbazill 671-16-9 Cytostaticum
366-70-1 Hydrochlorid
N-isopropyl-a-(2-methylhydrazino)-/>-toluamide
ИзС^)—СООСИ3 + Br2 -► Br—CH2—COOCH3
4-Methylbenzoesaure- 4-Brommethylbenzoesaure-
methylester methylester
764 P Procarbazin - Prochlorperazin
н5св-сн2-о-со со-о-снг-свн5
I I /NaH
H3C-N—NH
1,2-Bis-tbenzyloxycarbonyD-J-methyl- Natrium fiydrazm hydrid
Н5Св-СН2-0-С0 C0-0-CH2-C6H5
H3C —N—n-ch2-^^-cooch3
1 .NaOH 2-SOCtj
3.H2N-CH(CH3)j
2 Thionylchlortd
3 Isopropylamin
H5C6-CH2-0-CO co-o-ch2-c6h5
H3c-N-
-N'CH2-0"'
ch3
CO—NH—СН—СНз
CH3
HBr/CHjCOOH ^ |H3C_NH_NH_CH2_^~^_C0_NH_£H_CH3
I Procarbazin
USP 3 520 926 (Roche; ert. 21.7.1970; CH-Prior. 9.6.1961). GB-P 968 460 (Roche; Anm. 7.6.1962; CH-Prior. 9.6.1961). P. Zeller et al., Experientia 19,129 (1963).
D: Natulan® (Roche) F: Natulan® (Roche) GB: Natulan® (Roche)
I: Natulan® (Roche) J: Natulan® (Roche) USA: Matulane® (Roche)
Prochlorperazin
(Chlormeprazine)
58-38-8
84-02-6
5132-55-8
Maleat
Methansulfonat
Antiemeticum;
Ataracticum
2-chloro-10-[3-(4-methyi-l-piperazinyl)propyl]-phenothiazine
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