- ..
( ):
' HO
3-Benzoyl-i-hydroxy-
1-methyl-i-phenyl-
piperidin
2-Methyl-9-phenyl~ 2,3-dihydro-IH-mdeno [2J-c jpyridm
I
CH3
И; / Raney-Ni
-О
USP 2470 108 (Roche; ert. 1949; Anm. 1947). GB: Thephorin® (Roche)
Pheniramin
86-21-5
132-20-7 Maleat 3269-83-8 p-Aminosalicylat
Antihistaminicum
2-[a-(2-dimethylaminoethyl)benzyl]pyridine Cl
O'
CH2 — CN + NaNH2 +
о
Benzyleyanid Natrium- 2-Chlor-
amid pyndin
CN
fVcH
N
О
1. NaNH2 с
2. С1-СН2-СНг--М^ _С
1. Matriumamid
2. 2-0im*thylamrno-ethylchlorid
Phenyl-(2-pyridyl)-
acetcnitril
CN CH3
/3-C-CH2-CH2-N - £
„ CH3
V y— CH —CH2-CH2-N
l^tjl 4<:h3
714 P Pheniramin - Phenmetrazin - Phenobarbital
■^N [Cu
Benzylchlorid Pyridin
O-c*
1. NaNHz рь
2. a-CH2-CH2-N
С h3
О
t Natriumamid 2. 2-Dimethylamino-
2-Benzylpyridin (neben 4-Benzyl-pyridin)
USP 2 567 245 (Schering Corp.; ert. 1951; Prior. 1948). USP 2676964 (ScheringCorp.; ert. 1954; Prior. 1950). DBP 830 193 (Farbw. Hoechst; Anm. 1948).
DBP 832 153 (Farbw. Hoechst; Anm. 1948).
D: Avil® (Albert-Roussel)
Aviletten® (Albert-Roussel)
F: Triaminic® (Salvoxyl-Wander)-Komb. Triatussic® (Salvoxyl-Wander)-Komb.
GB: Danerai® (Hoechst)-(p>-Armnosaiicyiat) I: Inhiston® (Biomedica Foscama)
USA: Inhiston® (Upjohn)
Trimeton® (Schering)
Phenmetrazin
(Oxazimedrine)
134-49-6
1707-14-8 Hydrochlorid
Psychostimulans
3-methyl-2-phenylmorphotine
0“"_снг_снз ^ Propiophenon
-C—CH-Br
\=/ I
CH3
cf-Brompropiophenon
Нг/Р<1-С
,CH^
2-Benzylamino-
ethanot
O'
CH г
-О
C-CH-N
СНз 'еНг-еНг-ОН
ch-nh-ch2-ch2-oh
СНз
СХ»
H3C N
I Phenmetrazin
USP 2 835 669 (Boehringer Ing.; ert. 1958; D-Prior. 1952).
D:
F:
Cafilon® (Ravensberg)-Komb. Cafilon® (Merck-CIevenot)-Komb.
J: Cafilon® (Yamanouchi)-Komb. USA: Preludin® (Boehringer Ing.)
Phenobarbital
(Phenemalum;
Phenobarbiton)
50-06-6
57-30-7
7645-06-9
7645-05-8
Na-Salz
Ca-Salz
Mg-Salz
Hypnoticum;
Sedativum;
Anticonvulsivum
5-ethyl-5-phenylbarbituric acid
Phenobarbital - Phenoperidin P 715
^ch2 -CN Benzylcyanid
<Q>—CH2-COOC2H5
Phenylessigsaureethyl-
ester
iCOOC2n5
Oxalsaure-
diethytester
С00СгН5
CO
ОЧн
C00C2H5
C00C2H5
COOC2H5
P heny t malonsaure-diethyiester
ЦаОСгН5/С2Н5Вг Ethyl-bromid
Н5С2ч ^COOCzHs
-C4
COOC2H5
Ethylphenyl-
malonsaurediethyl-
ester
<^^>-CH2-C
Benzylcyanid
NaOCiH5/OC(OCaHsh
Diethyl -carbonat
COOC2H5
CHh
CN
a-Cyan-a-phenyl-
essigsaureethyl-
ester
NaOC2Hs/C2hsSr
Ethyl-
bromid
Н5С2Ч ^СООСгИй
c
2-Cyan-2-phenyl-
buttersaureethylester
HsC2 7n^nh NH
0NH
Phenobarbital
DRP 247 952 (Bayer; 1911).
USP 2 358 072 (Кау-Fries; ert. 1944; Anm. 1941).
D: Luminal® (Bayer)
Luminaletten® (Bayer)
Maliasin® (Knoll)-Salz mit Propylhexedrin (= Barbexaclonum)
Phenaemai® (ICN)
Phenaemalctten® (ICN)
Phenobarbyl Tabl. (Synochem)
Seda-Tablinen® (Sanorania) zahlreiche Komb.-Praparate F: Gardenal® (Specia)
Lenterules De Phenobarbital (Specia) zahlreiche Komb.-Praparate GB: Gardenal® (May & Baker)
Luminal® (Winthrop)
Parabal® (Sinclair)
Phenomet® (Woodward)
I: Comizial® (Ogna)
Gardenale® (Farmitalia)
Luminale® Bracco (Bracco)
Luminalette® (Bracco)
Sedofen® (Fabo) zahlreiche Komb.-Praparate J: Linasen® (Daiichi)
Phenobal® (Fujinaga-Sankyo)
Phenobarbital (Ohta; Fuso; Hamari;
Hishiyama; Hoei; Iwaki; Kaigai; Kuroishi; Maruishi; Nakakita; Nippon Shoji; Skano; Torii; Toyo S.-Ono; Yamada)
USA: Eskabarb® (Smith Kline & French)
Luminal® (Winthrop)
Phenobarbital (ICN; Lilly; McKesson; Merrell-National; Parke-Davis; Philips Roxane; Upjohn; Wyeth; Elder; Lederle) SK-Phenobarbital™ (SK&F)
Stental® Extentabs® (Robins)
Phenoperidin
(Fenoperidln)
562-26-5
3627-49-4
Hydrochlorid
Analgeticum
l-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxyIic acid ethyl ester
716 P Phenoperidin - Phenoxybenzamin - Phenoxymethylpenicillin
Ch-c
Acetophenon
(CH20)n
Paraform- 4-Phenylpipendin-aldehyd 4 -carbonsaureethyl-
ester-Hydrochtorid
Нг/PtO oder NaBHt
Q-CH - CH2 - CH2 - N
I
OH
Phenoperidin
,COOC2H5
A— C—CHj —CH2 —n;
COOC2H5
USP 2 951080 (Eli Lilly; ert. 30.8.1960; Prior. 5.8.1957).
USP 2 962 501 (Merck & Co.; ert. 29.11.1960; Prior. 19.9.1956).
F: R. 1406 (LeBrun)
G В: Operidine® (Janssen)
Phenoxybenzamin
59-96-1
63-92-3
Hydrochlorid
Vasodilatator;
Antihypertonicum
(a-8locker)
iV-(2-chloroethyl)-N-(l-methyl-2-phenoxyethyl)-benzylamine
Q-°
CH3
Propylen-
oxid
СНз
— CH2—CH —OH
J-Phenoxy-2-propanol
Thionyl-
chtond
CH3 I
-CH2-CH-CI
0-o-
1-Phenoxy-2-propylchlorid
H2N-CHz-CH;-OH
Ethanolamm
(2-AmiroethanoU
/ГЛ 'Н3 <Q-CH,-C
о-снг-сн-мн-снг-снг-он
Q-O-CH, —CH —
CH3 CH2-CH2-OH
./ socu
CH2-
■-O
Thionyl-
chlorid
-CH2-CH-N
Phenoxybenzamin
СНз CH2-CH2-C!
USP 2 599 000 (Smith Kline & French; ert. 1952; Prior. 1950).
D: Dibenzyran® (Rohm Pharma) USA: Dibenzyline® (Smith Kline & French)
GB: Dibenyline® (Smith Kline & French)
