- ..
( ):
Stovarsol (Specia) J: Neo Osvarsan® (Banyu)
GB: S. V. C. (May + Baker) Osvarsan® (Banyu)
Pyorex® (Bengue)-Komb.
Acetazolamid 59-66-5 Diureticum
(Acetazoleamid)
5-acetamido-l,3,4-thiadiazole-2-sulfonamide
hn-nh
I I coch N—N
2NH4S CN * H2N-NH2 -► H2M-C C = S -► НЫ'О'-СН
и i h2n ns ^h
s nh2
Ammonium- Hydrazin Hydrazin-A/,A/'- 2-Amino-5-mercapto-
rhodanid bis-{thiocarbamid] 1,3/-thiadiazol
[ "Bis-(thioharnstoff)'']
(CH3C0)20
Acetanhydrid
N-N
H3C-CO-NH^s^SH
2-Acetylamino-5-mer -capto-1,3/-lhiadiazol
Л V
НзС-СО-NH^s S02-CI
2-Acetylamino-1j3/-thiadiazol-5-sulfonylcblond
N-N
H3C-C0-NH^S^'S02-NH2
Acetazolamid
Acetazolamid - Acetohexamid - Acetophenazin A 7
USP 2 554 816 (American Cyanamid; ert. 1951; Prior. 1950).
R. O. Roblin, J. W. Clapp, J. Am. Chem. Soc. 72, 4890 (1950). Ahnliches Verfahren:
USP 2980679 (Omikron-Gagliardi; ert. 18.4.1961; I-Prior. 4.4.1957).
D:
GB:
Diamox® (Lederle)
Glaupax® (Baeschlin) Acetazolamide Chibret (Chibret) DefiltraQ® (Phygiene)
Diamox® (Th6raplix)
Diamox® (Lederle)
Diamox Sustets® (Lederle) Diamox® (Cyanamid)
USA:
Diuriwas® (Wassermann) [nidrase® (Omikron-Gagliardi) Acetamox® (Santen)
Diamox® (Lederle)
Didoc® (Sawai)
Zohnox® (Konto)
Diamox® (Lederle)
Acetohexamid
(Cydamide)
968-81-0
Antidiabeticum
l-[(p-acetyIphenyl)sulfonyl]-3-cyclohexylurea
H3c
ю-
nh2
1. NaNOj /HCI-CH3COOH
2. S02/Cu2Cl2_
4-Ammoaceto-
phenon
<y
S02-CI
H3c4
с
0*
4-Acetylbenzotsulfo-
n/lchtorid
H3C
V-Q-so,.
nh2
4-Acetylbenzolsulfon-
amid
1. KjCOj -Aceton
1.
3. wassr. HC1
2. Cyclohexyl-isocyanat
H3C
Acetohexamid
USP 3 320 312 (Lilly; ert. 16.5.1967; Prior. 28.4.1960).
DBP 1 177 631 (Lilly; Anm. 21.4.1961; USA-Prior. 28.4.1960). DBP 1 135 891 (Hoechst; Anm. 30.6.1960).
GB: Dimelor® (Lilly) I: Dimelor® (Lilly)
J: Dimelin® (Shionogi) USA: Dymelor® (Lilly)
Acetophenazin
2751-68-0
5714-00-1
Di male at
Neurolepticum
10-[3-[4-(2-hydroxethyl)-l-piperazinyl]propyl]phenothiazin-2-yl methyl ketone
8 A Acetophenazin - Acetrizoesaure - Acetylcystein
I
CH3
1 NaNH}
2. Bf-ICHzla-Cl ). Nairiumamid 2. 1-Brom-3-chlor-propan
2-Acetylphenoth)a2in
4 IT I
СНг
CH2
CH2-CI
СНз
2-Acetyl -10-! 3-cMorpropyl)-phenothiazin
HN^_^s|-CH2-CH2-OH
1-(2-Hydroxyethyl)-
piperazin
г it if
CH2 СНз
CH2
CH2 -N N-CH2-CH2-OH \_f Acetophenazin
USP2985 654 (Schering Corp.; ert. 23.5.1961; Prior. 21.9.1956). USA: Tindal® (Schering)
Acetrizoesaure
(Acetrizoate de sodium; Sodium Acetrizoate)
85-36-9
129-63-5 Na-Salz 131 -60-2 Methylglucamin-Salz
Rdntgenkontrastmittel
‘benzoic acid, 3-(acetylamino)-2,4,6-triiodo-.
COOH
i. Ji J
nh2
3-Amino-2,4,6-trijodbenzoesaure
(H3C-C0)20
Acetanhydnd
USP 2 611786 (Mallinckrodt; ert. 1952; Anm. 1950; Prior. 21.7.1948). Ausgangsprodukt:
H. Kretzer, Ber. Dtsch. Chem. Ges. 30,1944 (1897).
F: Vasurix® (Guerbet)
GB: Diaginol® (May & Baker) J: Diaginol® (Banyu)
USA: Cystocon® (Mallinckrodt)
Pyelokon-R® (Mallinckrodt) Salpix® (Ortho)
Acetylcystein
616-91-1
19542-74-6 Na-Salz
Sekretolyticum
/V-acetyl-L-cysteine
HS-CH2-CH-C00H • HCl • H2O + |CH3C0)20 NH2
l - Cystein-Hydrochtorid-Monohydrat Acetanhydnd
HS-CH2-CH-COOH
NH-CO-CH3
Acetylcystein
Acetylcystein - Acetyldigitoxin A 9
DOT 16,41(1980).
USP 3 091 569 (Mead Johnson; ert. 28.5.1963; Anm. 26.8.1960).
USP 3 184505 (Mead Johnson; ert. 18.5.1965; Anm. 18.6.1962).
H. A. Smith u. G. Gorin, J. Org. Chem. 26,820 (1961).
Ammoniumsalz (Mucolyse von Lungenmucussekretion durch Insufflation): DOS 2 305 271 (Bristol-Myers; Anm. 2.2.1973; USA-Prior. 3.2.1972).
D:
F:
GB:
Fluimucetin® (Inpharzam) Fluimucil®-100/-200 (Inpharzam) Mucolyticum ,,Lappe“® (Lappe) Rinofluimucil® (Inpharzam)-Komb. Mucomyst® (Allard)
Airbron® (Duncan, Flockhart) Parvolex® (Duncan, Flockhart)
I: Fluimicil® (Zambon) Mucisol® (Deca)
Mucomist® (Bristol)
J: Acetein® Sol (Senju)
A. R. B. Liq. (Tokyo Tanabe) A. R. B. Sol. (Shiraimatsu) Mucofilin® Sol. (Eisai)
USA: Mucomyst® (Mead Johnson)
Acetyldigitoxin
1111-39-3
Herzglycosid
a-acetyldigitoxin
Lanatosid A
b '
□ igitoxin + H3C—C(OC2H5)3 -* Acetyldigitoxin
Orthoessigsaure-
triethylester
10 A Acetyldigitoxin - а-Acetyldigoxin
a A. Stoll et al„ Helv. Cfaim. Acta 34, 397 (1951).
O. Gisvold, J. Pharm. Sci. 61,1320 (1972).
HP 155 716 (Richter Gedeon; Anm. 20.1.1968).
DBP 925 047 (Sandoz; Anm. 1954, CH-Prior. 1952). b DBP 2010 422 (Boehringer Ing.; Anm. 5.3.1970).
Weiteres Verfahren:
DBP2206 737 (BoehringerMannh.; Anm. 12.2.l972)(siehe a*Acetyldigoxin).
D: Acylanid® (Sandoz) F: Acylanide® (Sandoz)
USA: Acylanid® (Sandoz)
а-Acetyldigoxin 5511 -98-8 Herzglycosid
* Card-20 (22) enolide, 3-[(0-3-0-acetyl-2,6-dideoxy-/3-D-ribohexapyranosyl-(l —*■ 4)-0-2,6-dideoxy-/5-o-ribo hexopyranosyl-(l—*4)-2,6-dideoxy-/3-D-hexopyranosyl)oxy]-12,14-dihydroxy (30, 5/3,120)
a
HO
OH
Lanatosid С
enzymatische
Hydrolyse
[Digilariidase]
0-C0-CH3
a-Acetyldigoxin
