- .
ISBN 5-98657-009-
( ):
DAS 2 429 101 (Kefalas; Anm. 18.6.1974; GB-Prior. 25.6.1973).
D: Ciatyl® (Tropon) I: Sordino!®' (Bracco)
GB: Ciopixol® (Lundbeck)-Decanoat
Cloperastin 3703-76-2
l-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]piperidine
Antitussivum
Cloperastin - Clopirac - Clorexolon С 235
CI-<Q>-CH-OH
4-Chlorbenzhydrol
) NaNHj
2 С!-СНг~СНг-Н^)
1. Natriumamid
2. 1-(2-Chlorethyl)-piperidin
Cl0 - CH2 - CH2 - N^>
Cloperastin
GB-P 670622 (Parke Davis; Anm. 1948; CH-Prior. 1947).
Salz mit 2-[4-(2-Hydroxyphenyl)-benzoyl]-benzoesaure:
GB-P 1 179945 (Yoshitomi; Anm. 7.7.1967, J-Prior. 7.7.1966; 16.8.1966, 15.11.1966 und 1.3.1967). J: Hustazol® (Yoshitomi)
Clopirac 42779-82-8 Antiphlogisticum
l-(p-chlorophenyl)-2,5-dimethyJpyrrole-3-acetic acid
ci
ci
о 0
II II
НзС-С-(СН2)2-С-СНз +
Hexan-2,5-dion
Jl -
NH2 • 4-Chioranilm
НзС-^у-СНз
CH3
1. CH20/HN /CHjCOOH СНэ
2 CH3I_
1 Formaldehyd/Oimethylanmn
2 Methyljodid
НзС^ч^СНз I"
v-
-Ц-
CH2-N-CH3
I
CH3
1 NaCN / (CHjljSO
2 KOH/C2HsOH
3 HCl
I. Natrium-CH3 cyand
i CH2-C00H
I
I Clopirac
DOS 2 261 965 (Continental Pharma; Anm. 18.12.1972; B-Prior. 23.12.1971, 22.6.1972).
C. Gillet et al., Eur. J. Med. Chem. Chim. Ther., 11, 173 (1976).
Clorexolon 2127-01-7 Diureticum
6-chloro-2-cyclohexyl-3-oxo-5-isoindolinesulfonamide
4-Chtor-
phthalimid
Cyclohexyl-
amm
4-Chlor-W-cyclohexyl-
phthalimid
236 С Clorexolon - Clorprenalin - Clortermin
о
S-Chlor-2-cyclohexyt-1 -isoindDlon
1. NaN02/HCl
2. S02/CH3COOH/CuCl
Ctorexoton
DOT 2,128(1966).
Belg-P 620654 (May & Baker; Anm. 25.7.1962; GB-Prior. 28.7.1961).
F; FlonatriJ® (Specia) GB: Nefrolan® (May & Baker)
Speciatensol® (Specia)-Komb. J: Nefrolan® (Teikoku Zoki)
Clorprenalin
3811-25-4
5588-22-7
Hydrochlorid-Monohy-
drat
Bronchospasmolyticum
l-(o-chlorophenyl)-2-isopropyiaminoethanol
a
-CH2-Br
Cl
С5~ГСНз
8г; /{peroxid |
Cl
C5-rc
2-Chloracetophenon
w-Brom-2-chlor-
acetophenon
(2-Chlorphenacyibromid)
Cl
^^)-СН-СНг-Вг
OH
USP 2 816 059 (Lilly; ert. 1957; Anm. 1956).
Cl
-H3
V-CH-CH2-NH-CH - CH3 I OH
Clorprenalin I
Aremans® (Zensei) Asthone®(Eisai) Bronocon® (Wakamoto) Gopinerin® (Nippon Shoji) Clorprenaline HCl (Kongo) Conseit® (San-A)
Cosmoline® (Chemiphar) Fusca® (Hoei)
Kalutein® (Tatsumi) Neoasutoma® (Nihon Yakulim) Pentadoll® (Showa)
Propran® (Kobayashi Kako)
Clortermin
10389-73-8
10389-72-7 Hydrochlorid
Appetitzugler
o-chloro-a,a-dimethylphenethyIamine
Clortermin - Clostebolacetat - Clotiazepam С 237
\=/ \—/ Aceton W |
CH3
Cl Cl Cl
CH3
2 -Chlorbenzylchlorid 2-Chlorberzyt- !-(2-Chlorphenyl)-
magnesiumchlorid 2-methyi-2-propanoi
CHjCOOH / NaCN / H*S04
(
S.. i
Cl
Clortermin
CH3
C-NH2
I
СНз
USP 3 415 937 (Ciba; ert. 10.12.1968; Anm. 1.12.1966; Prior. 31.8.1964).
USA: Voranil® (USV)
ClOStebOlacetat 855-19-6 Anabolicum
4-chloro-17/S -hydroxyandrost-4-en-3-one-acetate
O-Acetyltestosteron Wasserstoff-
peroxid
USP 2 953 582 (Societa Farmaceutici Italia; ert. 20.9.1960; Anm. 26.10.1956; I-Prior. 23.4.1956). USP 2933 510 (Julian Labs.; ert. 19.4.1960, Prior. 3.2.1955).
D: Deidral® (Montedison-Pharma)-Komb. I: Alfa-Trofodermin®(Farmitalia)
Megagrisevit® (Montedison Pharma) J: Steranabol® (Sumitomo)
Steranabol® (Montedison Pharma)
СI Otiazepa m 33671 -46-4 Tranqui lizer
5-(o-chlorophenyl)-7-ethyl-l,3-dihydro-l-methyl-2//-thieno[2,3-e]-l,4-diazepin-2-one
238 С Clotiazepam - Clotrimazol
H5C2^v'Sn^NH—СНз
4,0
3-(2-Chlorbenzoyl)-5-
ethyl-2-methylamino-
thiophen
+ H2N —CH2“COOC2HS • HCl
Glycinethy tester-Hydrochlorid
H5C2^-Ss^NH-CH3
M
Ъ=0
d^a
+ CI-C0-CH2-NH-CO-0-CH2
N-Benzytoxycarbonylglycylchlorid
CH3
H5C2^s^N-CO-CH2-NH-СО-О-СНг-^у1 \=0
C^cl
CH3 с I
H5C2'-*'' “Ч-И — C° — CH2“ Nh2
Crc
c=0
Cl
Pyridin /CH3CQOKI Benzol
Clotiazepam
XX
6
NH2
‘c=o
c,
H5C2-^'SV"N-f>°
Нг^-СН2-СООСгН5- HCt/Pyridin
(H3C0)2S02
Dimethylsulfat
Natrium-met hyl at
Clotiazepam
5-(2-Chtorphenyl)-7-ethyl-1,3-dihydro-2 H -thiono{2J3-ejlJ4-diazepin-2-on
DOF 1,363 (1976).
DOT 16,13(1980).
DOS 2 107 356 (Yoshitomi; Anm, 16.2.1971; J-Prior. 17.2.1970, 23.2.1970, 7.3.1970, 25.6.1970,
31.7.1970).
USP 3 849 405 (Yoshitomi; ert. 19.11.1974; J-Prior. 17.2.1970,23.2.1970, 7.3.1970. 25.6.1970,
31.7.1970).
D: Trecaimo® (Tropon)
1: Lieze® (Yoshitomi)
Clotrimazol 23593-75-1
l-(ochloro-a,a-diphenylbenzyl)imidazole
Antimykoticum
Clotrimazol - Cloxacillin С 239
О
/s=N N(CjH*l» + hn i
t I -
Triethyl-
amir
2-Chlortri-
Imidazol
Clotrimazol
phenylmethyl-
chlond
DOT 10,32(1974).
DBP 1 617 481 (Bayer; Anm. 15.9.1967).
DAS 1670 976 (Bayer; Anm. 29.1.1968).
USP 3 660 577 (Bayer; ert. 2.5.1972; D-Prior. 15.9.1967).
USP 3 705 172 (Bayer; ert. 5.12.1972; D-Prior. 15.9.1967).
D: Baycuten® (Bayropharm)-Komb. J: Empecid® (Yoshitomi/'Baver)
Canesten® (Bayer) USA: Lotrimin® (Delbay)
F: Trimysten® (Roger Bellon) Gyne-Lotrimin® (Deibay)
