- .
ISBN 5-98657-009-
( ):
GB: Clomid® (Merreil) J: Clomid® (Shionogi)
USA: Clomid® (Merrell-National)
Clomipramin ЗОЗ-49-1 Antidepressivum
17321 -77-6 Hydrochloric!
3-chloro-5-[3-(dimethylamino)propyl]-10,n-dihydro-5#-dibenz[b,f]azepine
3-Chlor-10,11-dihydro-5H-di-benzo[b,f jazepin
C0C12
Phosgen
HO-(CH2)3-N(CH3); ,
3-0imethylamino-
propanol
З-СЫог-10,11-dihydro-SH-di-benzo{b,f jazepin
NaNHi
2 C1-ICH2)3-N1CH3)2
1 Natnumamid 2. I-Oimethylamino-propylchlond
Clomrpramin
DOT4,143 (1968); 9,218 (1973).
USP 3 515 785 (Geigy; ert. 2.6.1970; CH-Prior. 6.12.1958; 12.1.1959). DBP 1 161278 (Geigy; Anm. 5.12.1959; CH-Prior. 6.12.1958,12.1.1959). CH-P 371 799 (Geigy; Anm. 6.12.1958).
P. N. Craig et al., J. Org. Chem. 26,135 (1961).
232 С Clomipramin - Clonazepam - Clonidin
Ausgangsprodukt:
DBP 1166200 (Geigy; Anm. 1959; CH-Prior. 1958,1959).
USP 3 056 774 (Geigy; ert. 1962; CH-Prior. 1958).
USP 3 056 776 (Geigy; ert. 1962; CH-Prior. 1959).
D: Anafranil® (Geigy) I: Anafranil® (Geigy)
F: Anafranil® (Geigy) J: Anafranil® (Fujisawa)
GB: Anafranil® (Geigy)
Clonazepam 1622-61-3 Anticonvulsivum
5-(»chlorophenyl)-l,3-dihydro-7-nitro-2ff-l,4-benzodiazepin-2-one
p
N02 § ^^-NH_C4/
2-Chlor-2 - 2-Amino-2'-
nitrobenzo- chlorbenzo-
phenon phenon
HHitl. CH2-NHj I PyndinJ
6”
DOT 9, 237,487,489 (1973).
L. H. Stembachet al., J. Med. Chem. 6,261 (1963).
USP 3 116203 (Hoffmann-LaRoche; ert. 31.12.1963; Prior. 14.3.1962).
USP3 123529 (Hoffmann-LaRoche; ert. 3.3.1964; Prior. 9.3.1962)
USP 3 121114 (Roche; ert. 11.2.1964; CH-Prior. 2.12.1960).
USP 3 203 990 (Roche; ert. 31,8.1965;Prior. 27.6.1960,20.4.1961,21.3.1962). USP 3 335 181 (Roche; ert. 8.8.1967; Anm. 17.4.1964).
D: Rivotril® (Roche) I: Rivotril® (Roche)
F: Rivotril® (Roche) USA: Clonopin® (Roche)
GB: Rivotril® (Roche)
Clonidin 4205-90-7 Antihypertonicum
4205-91-8 Hydrochlorid
H 0
5-(2-Chlor-phenyl) -2-oxo-
2.3-dihydro-IH-
1.4-berzodiazepin
2-(2,6-dichloroanilino)-2-imidazoline
Clonidin - Clopamicf С 233
ci
nh2 + nh4scn —
ci
2,6-Oi’chlor- Ammonium-amlm rhodanid
Л/-(2,6-0|сЫсг-
phenyl)-thio-
harnstoff
Methyl £ jodid
Cl
0-
S-CH3
NH-C
NH
H2N-CH2-CHz-NH2
Ethytendiamm
Cl
Clonidin
DOT4,74 (1968); 9, 97 (1973).
DBP 1 303 141 (Boehringer Ing.; Anm. 9.10.1961).
USP3202660 (Boehringer Ing.; ert. 24.8,1965;D-Prior. 9.10.1961).
USP 3 236 857 (Boehringer Ing.; ert. 22.2.1966; D-Prior. 9.10.1961,4.10.1963).
Belg-P 653 933 (Boehringer Ing.; Anm. 2.10.1964; D-Prior. 4.10.1963; 31.7.1964).
GB-P 1 016514 (Boehringer Ing.; Anm. 2.10.1962; D-Prior. 9.10.1961).
GB-P 1034 938 (Boehringer Ing.; Anm. 28.9.1964; D-Prior. 4.10Л963; Zusatzzu GB-P 1016 514). Alternativ-Synthesen:
DAS 1 770 874 (VEB Arzneimittelwerke Dresden; Anm. 12.7.1968).
DAS 2 505 297 (Lentia; Anm. 7.2.1975; A-Prior. 5.4.1974).
D: Catapresan® (Boehringer Ing.)
Combipresan® (Boehringer Ing.)-Komb. Dimapres® (Dieckmann)-Komb. Isoglaucon® (Boehringer Ing.)
F: Catapressan® (Boehringer Ing.)
I: Catapresan® (Boehringer Ing.) Ipotensium® (Pierrel)
Isoglaucon® (Boehringer Ing.)
GB: Catapres® (Boehringer Ing.)
Dixarit® (WB)
J: Catapres® (Tanabe)
USA: Catapres® (Boehringer Ing.)
Combipres® (Boehringer fng.)-Komb.
Clopamid
636-54-4 Diureticum
4-chIoro-jV~(c/j-2,6-dimethylpiperidino)-3-sulfamoyl-benzamide
COOH
4-Chlorbenzoe-
saure
C(S03H
Chlor-
sulfon-
saure
Thionyl-
cfilorid
CI-SO2
Cl-
H2N-SO2
Cl—\ 'Vco-ci
t-Amino-c is-2,6-dimethyl-piperidin
H2N-SO2
Cl—\^“COOH
3-Aminosulforiyl-4-chlor-
benzoesaure
НгИ-БОг
CO-NH'
рн3
&
CH3
Clopamid
234 С Clopamid - Clopenthixol - Cloperastin
E. Jucker, A. Lindenmann, Helv. Chim. Acta 45,2316 (1962).
CH-P 412 891 (Sandoz; Anm. 6.6.1961; Zusatz zu CH-P 396905).
CH-P 396 905 (Sandoz; Anm. 9.11.1960).
CH-P 436 288 (Sandoz; Anm. 11.6.1963).
Komb. mit Dihydroergocristin und Reserpin:
USP 3 567 828 (Sandoz; ert. 2.3.1971; Anm. 12.8.1968; CH-Prior. 17.8.1967). DAS 1792 271 (Sandoz; Anm. 13.8.1968; CH-Prior. 17.8.1967).
Brinaldix® (Sandoz) Briserin®/mite (Sandoz)-Komb. Viskaldix® (Sandoz)-Komb. Brinaldix® (Sandoz)
Brinedine® (Sandoz)-Komb.
GB: Brinaldix® (Sandoz)
Viskaldix® (Sandoz)-Komb. I: Brinaldix® (Wander)
USA: Brinaldix® (Sandoz)
Clopenthixol
982-24-1
633-59-0 Dihydrochlorid
Neurolepticum
4-[3-(2-chlorothioxanthen-9-ylidene)propyl]-l-piperazineethanol
ci
CH I
CH2 CH3 СНз-N
чснэ
Chlorprothixen
hn N-снг-снг-он
!-(2-Hydroxyethyl)-piperazin
130eC,48Stdn
‘Cl
CH I
CH 2
CH2- _N- СНг- CH2- OH
Clopenthixol
DOT 9, 229(1973).
USP3116 291 (Kefalas; ert. 31.12.1963; DK-Prior. 4.12.1958).
DBP 1 231254 (Kefalas; Anm. 1960; DK-Prior. 1959).
USP 3 149 103 (Kefalas A/S; ert. 15.9.1964; DK-Prior. 14.7.1959).
GB-P 932 494 (Kefalas; Anm 3.12.1959; DK-Prior. 4.12.1958, 14.8.1959). Altemativ-Synthesen:
DBP 1443 983 (Roche; Anm. 16.1.1962; CH-Prior. 8.2.1961, 30.3.1961). DBP 1795 506 (Kefalas; Anm. 3.12.1959; DK-Prior. 4.12.1958,14.8.1959). DOS 1 918 739 (Egyesiilt; Anm. 12.4.1969, H-Prior. 12.4.1968). Isomeren-Trennung:
