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. .: , 2007. 608 c.
ISBN 5-98657-009-
( ): pharmazeutischewirkstoffe1982.djvu
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Vitamina C® Marvin (Panther-Osfa Chemie) Vitamina C® Saif (Saif)
Vitamina C® Vca (Esterfarm)
Vitamina C® Vita (Vita)
Vitascorbin® (Sirt-BBP)
Komb.-Praparate J: Ascorbic Acid (Horita; Kowa)
Ascoyl® (Shionogi)
Hicee® (Takeda)
Viscorin® (Daiichi)
Vitacimin® (Takeda) zahlreiche Komb.-Praparate USA: Ascorbic Acid (Vitarine)
Cetane® (OTC)
Cevi-Bid (Geriatric Pharm.)
Ce-Vi-Sol® (Mead Johnson)
Ferancee® (Stuart)
Solucap C™ (Pharmacare)
Vitamin С (Squibb)
Vitron-C® (Fisons)
Asparaginase 9015-68-3 Cytostaticum
(L-Asparaginase)
* asparaginase L-Asparagin-Amidohydrolase relative MolekUlmasse 133 000 ±5000 Durch Abtrennung aus Bakterienkulturen wie z. B. Escherichia coli, Serratia marcescens, Erwinia aroideae, Erwinia atroseptica, Erwinia carotovora. Ho et al„ ]. Biol. Chem. 245,3708 (1970). DAS 1 642615 (Bayer; Anm. 27.12.1967). DAS 1 942 833 (Secret, of State for Social Services, London; Anm. 22.8.1969, GB-Prior. 23.8.1968). DAS 1 942 900 (Secret, of State for Social Services, London; Anm. 22.8.1969; GB-Prior. 23.8.1968).
D: Crasnitin® (Bayer) I: Crasnitin® (Bayer)
F: Kidrolase (Specia) USA: Elspar® (Merck + Co.)
Atenolol 29122-68-7 Betablocker
2-[/>-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide
Atenolol - Atropin A 63
/^~V_ NaCN/NaOH/OMF, 130°C л /F~\ л H20
HOOC-CH-(^J)-OH -!-* CH2-fV0H —*-»■ HjN-C-CHi-^VoH
nh2 0
pL-i-Hydroxyphenylglycin I - Hydroxy benzy Icy arid 4-Hydroxyphenytacetamid
J££-д H2N-c-cH2-<fr^>-0'-cH2^j -w~CH~CHl»
Epichlof- np«rid»n И \—/ Isopropytamm
hydrin 0
4-{2,3-Epoxypropyloxy)-phenytacetamid
ОН СНз
H2N - с-с нг-^^-о-с H2 - CH - CH2 - NH - CH - CH3
0
DOF1,7 (1976); 2, 70(1977).
DOT 16,30(1980).
USP 3 663 607 (Id; ert. 16.5.1972; GB-Prior. 21.2.1969).
USP 3 836671 (ICI; ert. 17.9.1974; GB-Prior. 21.2.1969, 24.9.1969,18.11.1970 und 19.11.1970). DOS 2 007 751 (ICI; Anm. 19.2.1970; GB-Prior. 21.2.1969 und 24.9.1969).
GB-P 1 285 038 (ICI; Anm. 21.2.1969; Laufzeit ab 24.9,1969).
Alternativ-Synthese:
GB-P 1391444 (ICI; Anm. 13.7.1971; Laufzeit ab 19.6.1972).
4-Hydroxy benzylcyanid:
GB-P 1 522 477 (ICI; Anm. 13.8.1974; Laufzeit ab 11.11.1975).
USP4154757 (ICI; ert. 15.5.1979; Anm. 22.5.1978).
D: Tenormin® (ICI-Pharma) GB: Tenormin® (Stuart)
F: Tenormine® (ICI-Pharma) Tenoretic® (Stuart)-Komb.
USA: Tenormin® (ICI)
Atropin
(D,L-Hyoscyamin)
51-55-8 51460-78-7 Borat 55-48-1 Sulfat
Anticholinergicum; Mydriaticum; Spasmolyticum
* 1 он,5 aH-tropan-3a-ol( ± )-tropate(ester)
Durch Extraktion von Solanaceen-Drogen, insbes. Atropa belladonna, Hyoscyamus niger u. a.
Bei vorsichtiger Extraktion wird zunachst L-Hyoscyamin erhalten, das in ethanolischer Losung durch Zusatz von Alkali zu Atropin. racemisiert werden kann.
Ullmann, 3. Aufl., Bd. 3, 201 f.
Ullmann, 4. Aufl., Bd. 7,151.
64 A Atropin - Atropinmethonitrat
D: Atropin in der Ophtiole® (Mann) Atropinol® Augentropfen (Winzer) Atropin. sulfurie. Thilo® (Thilo) Atropinum sulfuric. Amphiolen®/ Compretten® (Cascan)
Komb.-Prap.
F: Atropine Aguettant (Aguettant) Atropine Houde (Houde)
Atropine Lavoisier (Chaix et Du Marais)
Atropine Martinet (Martinet)
Chibro-Atropine
(Merck Sharp + Dohme Chibret)
Dosatropine (Martinet)
zahlreiche Komb.-Praparate GB: Komb.-Prap.
I: Generics (Bruschettini, Farmigea, Lirca, Tubi Lux Farma)
Liotropina® (Sifi)
Komb.-Prap.
J: Generic-Prap.
USA: Atratan® (Mallinckrodt)
Atropine Sulfate
(Allergan; Burroughs Wellcome; Lilly; Smith, Miller & Patch; Wyeth) Atropisol® (Smith, Miller & Patch) Isopto® Atropine (Alcon)
Atropinmethonitrat
(Atropinmethylnitrat; Methylatropine Nitrate)
52-88-0
Anticholinergicum;
Mydriaticum;
Spasmolyticum
!-methylatropinium nitrate
HjC'
"n.
CO-CH-CH2-0H + НзС-ONOz
Methylnitrat
Atropin
НзС'
СНз
^N.
n
CO-CH-CH2-OH
6
N03
Atropinmethonitrat
H3C'
СНз Cl
Atropin
Methylchlorid AgjSOt
H3C
CH3
V O-CO-CH-CHz-0 6
W-Methylatropin-chlorid
W-Methylatropin-sulfat
Atropinmethonitrat
DRP 137622 (Bayer; 1901).
DRP 138443 (Bayer; 1901).
D: Belladonna-Exclud® (Reiss)-Komb.
Bronchovycrin® (Endopharm)-Komb. Brox® (Wachter)-Komb.
Myocardon® (Byk GuIden)-Komb. Perasthman Inhalat (Bissamz)-Komb.
Perphyllon® (Homburg)-Komb. zahlreiche weitere Komb.-Praparate GB: Eumydrin® (Winthrop)
USA: Metropine® (Pennwalt)
Azacosterol - Azacyclonol - Azapetin A 65
Azacosterol 313-05-3 Hypocholesterinamicum
1249-84-9 Dihydrochlorid
17/?-[(3-(dimethylamino)pr°pyl]methylamino]androst-5-en-3^-ol
Prasteron 3-0imethylaminO'
(s. S. 74q) propylamm
LiAIHa / Dioxan
LHhiuin-
atanat
USP 3 084156 (Searle; ert. 2.4.1963; Prior. 30.11.1961, 28.3.1961). R. E. Counsell et al., J. Med. Pharm. Chem. 5,1224 (1962).
USA: Omitrol® (Searle)
Azacyclonol
115-46-8 1798-50-1 Hydrochlorid
Ataracticum
a,a-diphenyl-4-piperidinemethanol
H5C20
У0И H;/PtO
0 u
Azacyclonol
Srombenzol Isonicotinsaure-brw. Phenyl- ethytestef magnesium -bromid
USP 2 804 422 (Merrell; ert. 1957;Prior. 1954).
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