- .
ISBN 5-98657-009-
( ):
Menadiol-bis-
dinatriumphosphat
(Menadiol sodium diphosphate)
84-98-0
131-13-5
6700-42-1
Menadioldiphosphat Tetranatrium-Salz Tetranatrium-Salz-Hexahydrat
Antihamorrhagisches
Vitamin
: 1,4-naphthalenediol, 2-methyl-, bis(dihydrogenphosphate)-disodium salt
,CH3
Menadion (s. S. 554)
Нг/Pd-C oder NajSjOs
1 P0Cl3
2 H20
3 NaOH
Menadiol (2-Methy(-1,4-naphthalindiot =
2-Methyl-1,4 -naphthohydrochinon)
Menadiol-bis-di-
natriumphosphat
L. F. Fieser et al., J. Am. Chem. Soc. 62,228 (1940). USP 2 380621 (Roche; ert. 1945; CH-Prior. 1942). USP 2 345 690 (Roche; ert. 1944; Anm. 1941).
USP 2 354 132 (Roche; ert. 1944; Anm. 1940).
554 M M.-bis-dinatriumphosphat - Menadiol-diacetat - Menadion - M.-natriumbisulfit
GB: Synkavit® (Roche) J: Kativ® (Takeda)
I: Carbocaina® (Pierrel) USA: Synkavite® (Roche)
Carbocaina® Con Adrenalina (Pierrel)
Menadiol-diacetat
(Acetomenadion; Acetomenafton)
573-20-6
Antihamorrhagicum
: 1,4-naphthalenediol, 2-methyl-diacetate
,снэ
Нг/Pd-C Oder Ма2ЗгОй
,CH3
Menadion (S. S. 554)
OH
Menadiot
(Н3С-С0)г0
О-СО-СНз j .СНз
0—CO —CHj Menadiol -diacetat
Horii et al., Pharm. BuiJ. (Tokyo) 5, 82 (1957).
GB: Myolgin® (Cox-Continental)-Komb. Pemivit® (Duncan, Flockhart)-Komb.
J; KatiV® (Takeda)
Menadion
{Menaphthon; Menaquinone; Vitamin K3)
58-27-5
Antihamorrhagisches
Vitamin
2-methyl-1,4-naphthoquinone
ли СгОз oder МагСггО? Oder
H202 Oder HNOj
2-Methylnaphthalin
0
Menadion
a Oxidation mit Chromsaure und Derivaten:
L. F. Fieser et al., J. Am. Chem. Soc. 61,2559, 3216 (1939).
USP 2 402 226 (Velsicol; ert. 1946; Anm. 1943). b Oxidation mit Wasserstoffperoxid:
Arnold und Larson, J. Org. Chem. S, 250 (1940).
USP 2 373 003 (Univ. of Minnesota; ert. 1945; Anm. 1941).
F: Bilkaby® (Bailly) J: Menadione (Kongo)
Menadion-natriumbisulfit 130-37-0 Antihamorrhagisches
(Menadion Sodium Bisulfite; Vitamin Menaphthone Sodium Bisulfite)
2-methyi-l,4-naphthoquinone sodium bisulfite
Menadion-natriumbisulfit - Mepacrin - Mepenzolat-bromid M 555
Menadion . Menadion-natrium-(s S 554) | bisulfit_
М. B. Moore, J. Am. Chem. Soc. 63, 2049 (1941).
B. R. Baker et al., J. Am. Chem. Soc. 64, 1096 (1942).
A. R. Menotti, J. Am. Chem. Soc. 65,1209 (1943).
USP 2 367 302 (Abbott; ert. 1945; Anm. 1940).
Vitamina К Vis (Vis)
J: Menadione Inj. (Nord)
I: K-Trombina® (Erba) Vitamina К Saif (Saif)
Mepacrin 83-89-6 Chemotherapeuticum
(Quinacrine; Atebrin) 69-05-6 Dihydrochlorid (Malariamittel)
6-chloro-9-(4-diethylamino-l-methylbutylamino)-2-methoxyacridine
2,4-Dichlor-
benzoesaure
&
0CH3
Cu/K2C03
h2n‘
4-Methoxyaniiin
(p-Anisidin)
OCH3
6,9-Dichlor*2-methoxy-
acndin
(2,5-Dichtor -7 -methoxy-acridin)
.0CH3
f"3 CjH,
H2N-CH-{CM2)3-N
2-Ammo-5-diethy(amino-
pentan
Phosphor-
oxychlond
,C2H5
CH3
HN-CH-(CH2)3-N'
0CH3 C2Hs
Mepacrin
DRP 553 072 (I.G. Farben; Anm. 1930).
A. Wingler, Angew. Chem. 61, 49 (1949).
F: CoIIagenan (Sobio)-Komb. Quinacrine® (Specia) Tenicridine® (Norgan)
GB: Quinacrine® (May & Baker) USA: Atabrine® (Winthrop)
Mepenzolat-bromid 76-90-4
3-hydroxy-l,l-dimethylpiperidinium bromide benzilate
Anticholinergicum
556 M Mepenzolat-bromid - Mephenesin
_ он
1 4 -с-соон + ci
6
Benzilsaure
СН3
3-СЫог-
methylpiperidin
ОН
О;-'0-0' м.-
О
СНз
3-(Diphenylglykoloyloxy)-1-methyl piperidin
Methyt-
bromid
OH
О-|-С0-°^
/СН3
Mepenzolat-bromid
USP 2 918 408 (Lakeside Labs.; ert. 1959; Prior. 1950).
F: Cantif® (Roger Bellon)
GB: Cantif® (M.C.P. Pharmaceuticals)
I: Cantril® Lakeside (Roger Bellon) Colibantil® (Tosi-NO)
Colum® (Jamco)
Enterocantril® (Roger Bellon)-Komb.
Gastropidil® (Fabo)
J: Eftoron® (Maruko Seiyaku) Sachicoron® (Zensei) Tendalin® (Nihon Yakuhin) Trancolon® (Fujisawa) USA: Cantil® (Lakeside)
Mephenesin 59-47-2 Muskelrelaxans
3-(<?-methylphenoxy)-l, 2-propanediol
i_^0H
CH3
o-Kresol
(2-Methyl-
phenol)
Cl“CH2-CH-CH2-OH
OH
3-Chlorpropan-1,2-diol
(Glycerinmonochiorhydrin)
Ю-0
-CH2-CH-CH2-OH OH
Mephenesin
b
CH3
* V'
CH2-0H
Glycid
Mephenesin
a E. R. Marie, J. Chem. Soc. (London) 101, 310 (1912). b GB-P 628497 (British Drug Houses; Anm. 1948).
D: Rhex ,,Hobein“® (Hobein)
F; Aigipan Baume (Actifarm)-Komb. Decontractyl® (Robert et Carriere) Traumalgyl® (Synlab)-Komb.
GB: Myanesin® (Duncan, Flockhart)
I: Relaxar® (Bouty)
J: Curaresin® (Kyoto) Myanol® (Chugai) Myoserol® (Sankyo) USA: Tolserol® (Squibb)
Mephenytoin - Mepitiostan M 557
Mephenytoin
(Methoin)
50-12-4
Antiepilepticum
5-ethyl-3-methyl-5-phenylhydantoin
О
ch2-cn
Benzylcyanid
0=C(0C2H5)2
Diethylcarbonat
MaOC2H5
NaOC2H5/C2H5Br
Etftyl-
bromid
b
HSCz4
ci
Propiophenon
HSC2 CO—NH2
\
CN
a-Ethyl-a-phenyl-
cyanacetamid
[2-Cyan-2-phenyl-
butyramid)
NaCN/{NHt}2C03
H4 C00C2Hs ,C
NH,
Hv co—NH2
0'
a-Phenyl-cyarr
essigsaureethylester
NaQCl
(H3C0)jSO2
Dimethyl-
sulfat
i-Ethyf-i*phenyl-
hydantom
(HaCQhSO?
