- .
ISBN 5-98657-009-
( ):
Remdue® (Biomedica Foscama)
USA:
Valdorm® (VaJeas) Benodil® (Kyowa) Dalmate® (Nippon Roche) Insumin® (Kyorin) Dalmane® (Roche)
Flurbiprofen F 427
Flurbiprofen
5104-49-4
Antiphlogisticum;
Analgeticum
2-fluoro- a-methyl-4-biphenylacetic acid
<^>-Br Br-l^^-C0CH3
q2n
Brombenzol A- Brom - 3 - nit ro -
acetophenon
1 NaNO?
2 HBF4
-COCH3
-COCH3
o2n'
Д-Acetyl-2-mtrobiphenyl
(J)——соснз
H2N
4-Acetyl-2-ammobiphenyl
CH2-COOH
4-Acetyl- 2-fluorbiphenyl
2-Fluor-Д-biphenylylessigsaure
-CH2-COOC2Hs
l CO(OC2Hsh/NaOC2H5
2- (CH30)2S02_
1 Diethyicarbonat,
2. Oimethytsulfat
COOC2H5
2-Fluor-4-biphenylylessigsaure-
ethytester
Flurbiprofen
\v_□ vig/THF
-MgBr
H3C—CO—COQNa / THF
Brenztraubensaure
(Na-Salz)
2-(2-Fluor-4-biphenylyl)-2 - hydroxypropionsaure
Poiyphosphofsaure
Flurbiprofen
2-(2-Fluor-4-biphenylyl)-
acrylsaure
DOF 1,323 (1976); 2, 486 (1977).
DOT 14,407(1978).
a DAS 1518 528 (Boots; Anm. 19.1.1965; GB-Prior. 24.1.1964).
USP 3 755 427 (Boots; ert. 28.8.1973; GB-Prior. 24.1.1964). b GB-P 1 514 812 (Boots; Anm. 4.4.1975; Laufzeit ab 31.3.1976).
Ahnliches Verfahren:
USP 3 959 364 (Boots; ert. 25.5.1976; GB-Prior. 24.5.1973).
Altemativ-Verfahren:
DOS 2 646792 (Mitsubishi Petrochemical; Anm. 16.10.1976; J-Prior. 23.10.1975, 31.7.1976). Razematspaltung:
DOS 2 809 794 (Boots; Anm. 7.3.1978; GB-Prior. 8.3.1977,18.1.1978).
D: Froben® (Thomae)
F: Cebutid® (Boots-Dacour)
GB: Froben® (Boots)
428 F Flurotyl - Fluroxen - Fluspirilen
FllirOtyl 333-36-8 Centrales Stimulans;
(Flurothyl) Convulsivum
F3C-CH2~OH —*-* F3C-CH2-ONa
IF3C-CH2-O-CH2-CF3I
1
I Flurotyl
F3C-CH2-OH ;>'r”CI-* F3C-CH2-Q-S02-<^^-CH3
2,2,2-Trifluorethanol
USP 3 363 006 (Pennsalt; ert. 9.1.1968; Prior. 29.12.1955,20.6.1960).
USA: Indoklon® (Ohio Med.)
FllirOXen 406-90-6 Inhafationsanastheticum
2,2,2-trifluoroethyl vinyl ether
F2C-CH2'OH » F3C-CH2-OK
2,2,2-Trifluorethanol j_Fluroxen_j
b 0-CH2-CF3
[Н*] 1 I Montmorillomt] , 240-2S0eC
H3C-CHO + 2F3C-CH2-OH j—H3C~-CH-0-CH2-CF3 --11-► Fluroxen
Acetaldehyd 2,2,2-Tr if luorethanol
a USP 2 830 007 (Air Reduction Comp.: ert. 1958; Anm. 1953). b USP2 870 218 (Air Reduction Comp.; ert. 1959; Anm. 1955).
USA: Fluoromar® (Ohio Med.)
FlUSpirilen 1841-l9-6 Neurolepticum
8-[4,4-bis(p-fIuorophenyI)butyI]-l-phenyf-l,3,8-triazaspirof4,5]decan-4-one
h5c6-Ch2-n^)=o + h*-Q + KCN -* *С^СН2-»^У"н
1-Benzyt-4-pipendon Anilin Kalium- 4-Anilmo-1-benzyl-4-
cyanid cyan piperidin
Fiuspirilen - Folescutol F 429
H2so4
h5c6-ch,-O<C0-NH2 HC0NHi-
v—/ N1
6
4-Aminocarbanyl-<*~anilino-
1-benzylpiperidin
For m-amid
H5C6-CH2-N^}TJ
NH
J
6
8-Benzyl-4-oxo-l-phenyl-
l^a-triaza-spiroKSJdecan
ofc
6
NH
(•0-1
CH-CH2-CH2-CH2-8f
4>-Bis-fi'<luofphenyl)-butyibromid
i-Oxo-1-phenyi-
1,3,8-triaza-
spiro^Sldecar»
CH-CH2-CH2-CH2-
Fluspirilen
6
DOT 9,235 (1973).
Belg-P 633 914 (Janssen; Anm. 20.6.1963; USA-Prior. 22.6.1962). USP 3 238216 (Janssen; ert. 1.3.1966; Prior. 22.6.1962, 20.6.1963). DAS 1 470125 (Janssen; Anm. 21.6.1963; USA-Prior. 22.6.1962).
D: Imap® (Janssen)
GB: Redeptin® (Smith Kline & French)
USA: Imap® (McNeil)
Folescutol
15687-22-6
36002-19-4 Hydrochlorid
Kapillartherapeuticum
6,7'dihydroxy-4-(morpholinomethyl)coumarin
НзС - со - - со—ch3
XT
H3C — CO—O' 1,2,4-Triacetoxybenzol
♦ а-сн2-с-сн2-соос2н5 ii 0
7-Chloracetessigsaureethylester
H0^
CH2-C1
4 - Chlormethyl - S,7-dihydroxycumarjn
CH2—N .0
FP-M 2035 (Lab. Dausse; Anm. 29.6.1962). D: Detensitral® (Karlspharma)-Komb.
F: Covalan (Dausse)
430 F Folinsaure - Folsaure
Folinsaure 58-05-9 Antianamicum;
(Calciumfoiinat) 1492-18-8 Ca-Salz Wachstumsfaktor 41927-89-3 Ca-Salz, Pentahydrat Ca-Salz: Antidot bei Oberdosierung von Folsaure-antagonisten
calcium iV-[p[[(2-ammo-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamate
OH
ЛУ
OH C00H
-CH2““NH—\ VC-NH-CH-CH2-CH2-COOH
N ‘ l| НС00НЛСН3СО)2О;4СвС
^ ^ ^ 0 -
H2N N N
Folsaure
(S. S. 430)
0H CHO__COOH
4-C~NH-CH-CH2-CH2-COOH
XX J »
H2N N N
A/~110)-Formytfolsaure
; ? ^ /Г\ 1
1 N CH2-NH—(' у- c-nh-ch-ch2-ch2-cooh ll^r Y \=/ II
Jj. I I 0
H2N N^^N
Folinsaure
USP 2 741 608 (Research Corp.; ert. 1956; Prior. 1950).
DOS 2 836599 (US Department of Commerce; Anm. 22.8.1978; USA-Prior. 22.8.1977).
C. Temple et al., J. Med. Chem. 22,731 (1979).
D: Leucovorin® (Lederle) J: Leucovorin® (Lederle)
F: Lederfotine® (Lederle) USA: Calcium Leucovorin (Lederle)
GB: Calcium Leucovorin (Lederle)
Folsaure 59-30-3 Antianamicum;
(Pteroylglutaminsaure) 6484-89-5 Na-Salz Wachstumsfaktor
iV,[4'-[[(2-amino-4-hydroxy-6-pteridy])methyl]amino]benzoyl]-L-(+)-glutamic acid
OH OH
SnCij edef Na^S^Q^ oder Нг/Р3 — С N' |
H2N''4r''NH2
NH 0
jj Ц _^ HWO; ^
h2n- "nh2 * H5c2o" ''ch* h2n"4AnH2 h2n-4Anh2
CN
Guanidin Cyanessigsaure- 2,4-0181^0-5-
ethylester hydro*ypyrimidin
OH
NH2
6-Hydroxy-2,4,5-triamino pyrimidm
Folsaure F 431
