- .
ISBN 5-98657-009-
( ):
Alfanonidrone® (Difer) u. Komb.-Prap.
Aeflorone30 Acetate (Merck Sharp & Dohme) Florinef® (Squibb)-Acetat Florotic® (Squibb)-Acetat-Komb.
Myconef® Ointment (Squibb)-Acetat-Komb.
408 F Fludroxycortid
FludrOXyCOrtid 1524-88-5 Glucocorticoid
(Fiurandrenollde)
6a-fluoro~ll^,166r,17,2l-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with acetone
H3C-C0-0-CH2
21-Acetoxy-16<r, !7a-epoxy-3/3-hydroxy-20-oxo-5-pregnen [aus Pr*gn*noion]
H3C-CO-O-CH2,
+ h,f2
H3C-C
Fluor- /V-Sromacetamid
wasser-
stoff
t. Cr03
2. HBr/CHjCOOH 3.lH3C-C0)iQ/tHC10tl
Chrom(VII-oxid
3. Acetanhydnd
h3c-co-o-ch2,
4C=0
1 CH3COOK/CH3COOH 2. Na2C03 /СН3ОН
H0-CH2.
mikrobiologische Hydroxylierung [ ArthroOotrys superba var atigcspora (ATCC 11572)]
oder [ Curentrghamella beakes (eeans (ATCC 3638 b)l
HO—CH2v
ho-ch2
HO—CH2
[HClOj
3,20-Dioxo-Ba-fluor- Aceton
11/?,16aJ17)21-tetrahydroxy-4-pregnen
a USP 3 014938 (Syntex; ert. 26.12.1961; Anm. 23.8.1960; MEX-Prior. 7.9.1959). USP 3 119749 (Syntex; ert. 28.1.1964; Anm. 17.11.1961; MEX Prior. 7.6.1961). USP 3 124 571 (Syntex; ert. 10.3.1964; MEX-Prior. 26.1.1960). Ausgangsverbindung:
P. L. Julian, J. Am. Chem. Soc. 72,5145 (1950).
USP2678 932 (SterlingDrug; ert. 1954; Prior. 1951). b USP 3126 375 (Syntex; ert. 24.3.1964; Anm. 11.6.1959; MEX-Prior. 13.6.1958). DBP 1131213 (Syntex; Anm. 6.6.1959; MEX-Prior. 13.6.1958).
Weitere Verfahren:
J. S. Mills et al., J. Am. Chem. Soc. 82, 3399 (1960); 81,1264 (1959).
USP 3203 869 (Syntex; ert. 31.8.1965; MEX-Prior. 11.10.1962).
Fludroxycortid - Flufenaminsaure - Flugestonacetat F 409
D; Sermaform® (LiJly)-Komb. Sermaka® (LilJy)-Komb. GB: Drenison® (Lilly) Haelan® (Dista) I: Drenison® (Lilly) J\ Drenison® (Dainippon) USA: Cordran® (Lilly) Cordran® N (Lilly)
Flufenaminsaure (Acide flufenamique) 530-78-9 16449-54-0 Antiphlogisticum; Al-Salz Antirheumaticum
ЛЧ «.«/.Mrifluoro-m-tolyhanthramlic acid
oc • С,/КгС03_ ГТ nd \
2-Chlor- 3-Trffiuor- ; Flufenaminsaure (
benzoesaure methylanilin
DOT 3, 139 (1967). FP 1 341 M (Parke-Davis; Anm. 11.8.1961). R. B. Moffett, B. D. Aspergen, J. Am. Chem. Soc. 82,1605 (1960). Salze mit Aminen: DOS 2 758 787 (T. Eckert; Anm. 29.12.1977).
D: Arlef® 200 (Parke-Davis) Baxaquil® (Helopharm) Sastridex® (Lindopharm) Surika® (Spitzner) F: Arlef® (Parke-Davis) GB: Arlef® (Parke-Davis) Meralen® (МеггеЛ) I: Arlef® (Parke-Davis) J: Achless® (Tatsumi) Arlef® (Parke Davis-Sankyo) Felunamin® (Hokuriku) Flufacid® (Wakamoto) Lanceat® (Maruko) Nichisedan® (Nissvn) Paraflu® (Dainippon) Reumajust A® (Horita) Ristogen® (Kowa Yakuhin) Romazal® (Tobishi) Saal-F® (Towa)
FlugeStOfiacetat 2529-45-5 Gestagen
(Flurogestone acetate)
9-fluoro-11Д17-dihydroxypregn-4-ene-3,20-dione- 17-acetate
a
3,20 - Oioxc - 16<x,V7- epoxy- Jod -4,9,1-pregnadien wassersioff
410 F Flugestonacetat - Flumedroxonacetat
■•-OH
-0-C0-CH3
IIД !7-D(hydroxy-3,20-dioxo-9a-fluor-4-pregnen
1 HOBr
2. Na2C03/H20/THF
3- HZF;/THP_
J. Hypobromjge Saure
' 'НзС ^Q”S°3H^CH3COOH
(СН3СО)гО
Acetanfiydrid
!. p-Tohjoisulfonsaure
Flugestonacetat
a C. G. Bergstrom et al., J. Am. Chem. Soc. 81, 4432 (1959). b USP2 892 851 (Searle; ert. 30.6.1959; Prior, 19.5.1958). USP 2 963 498 (Searle; ert. 6.12.1960; Prior. 11.5.1959).
USA: Cronolone® (Searle)
Flumedroxonacetat
987-18-8
Migranetherapeuticum; Gestagen
17-hydroxy-6a-(trifluoromethyl)pregn-4-ene>3,20-dione-acetate
-O-CO-CH3
17 - Acetoxyprogesteron
HC(OC2Hs)3
n-Toluolsulfonsaure
H5C20'
-O-CO-CH3
Orthoameisensaare-ethy! ester
!. CF3I / (Pyndin j, hv
2 HCl_
5 7nf(uormethy(joflid
GB-P 905 694 (Lovens Kemiske Fa., Laufzeit ab 14.3.1961; Prior. 18.3.1960, 8.6.1960). W. O. Godfredsen, S. Vangedal, Acta. Chem. Scand. 15, 1786 (1961).
D: Praemenstron® (Nordmark)-Komb.
Flumequin - Flumetason F 411
Flumequin 42835'25-6 Chemotherapeutikum
9-fIuoro-6,7-dihydro-5-methyl-l-oxo-ltf.5//-benzo[ij]quinolizine-2-carboxylic acid
COOC2H5
н
N^CH3
CH = C.
OOOC2H5 xN^CH3COOC2 Hs
■г НбС20 — СИ — с
COOC2H5
6-Fiuor-2-methyl- Ethoxymethylenmalonsaure-
1,2,3,4-tetrahydro- diethylester
ХСГ
I. Po(ypfiosphorsaure 2 NaOH / H20
DOT 14,365 (1978).
DOS 2 264163 (Riker; Anm. 29.12.1972; USA-Prior. 30.12.1971). USP 3 896 131 (Riker; ert. 22.7.1975; Prior. 2.11.1972, 30.12.1971).
F: Apurone® (Lab. Riker)
Flumetason 2135-17-3 Glucocorticoid (Flumethasone) 2002-29-1 Plvalat
6a,9-difIuoro- ИД17,21 -trihydroxy-16a-methylpregna-1,4-diene-3,20-dione
H3C-C0-0-CH2
[нсю4з/сн3соок
нзс-со-о-снг,
чс^о .(.-OH >-*CH3
h2f2 /thf/ch2ci2
Fiuor-
wass*f-
stoff
21 - Acetoxy- 3,20-dioxo- 6a-fluor-l7a-hydroxy-16cr-methyl-i.^-pregnadien [aus t6a-Methylpregnenolon] (s. S 686}
yV-Brom-
succinimid
H3C—СО—0—СН2.
NC=0
но^^^-чЫ-он
н T >”CH,
1. SeOj 2 KHCO-,
412 F Flumetason - Flunarizin
{Н3С)3С-С0-0-СН2ч
H* NH,
Flumetason-
21-0-{2,2-dimethyl-
propionatl
21~(2,2-Dimetbylpropiortyloxy)- Fluor-
